Alkadhi K A, Banks F W
Brain Res. 1984 Jul 23;306(1-2):388-90. doi: 10.1016/0006-8993(84)90393-7.
The effect of valproic acid (VPA) on synaptic transmission was investigated at the frog neuromuscular junction using electrophysiological methods. The drug caused a dose-dependent decrease in the quantal content of the endplate potential (EPP) and a significant reduction in the input resistance of the postjunctional membrane. There were no apparent changes in the resting membrane potential or the frequency of the miniature endplate potential (MEPP). These results suggest that VPA has pre- as well as postsynaptic actions, both of which could lead to suppression of synaptic transmission.
采用电生理方法在青蛙神经肌肉接头处研究了丙戊酸（VPA）对突触传递的影响。该药物导致终板电位（EPP）的量子含量呈剂量依赖性降低，并且使突触后膜的输入电阻显著降低。静息膜电位或微小终板电位（MEPP）的频率没有明显变化。这些结果表明，VPA具有突触前和突触后作用，两者均可导致突触传递受到抑制。
