由非环状前体一锅法合成3,5-二取代和多取代苯酚。
One-pot synthesis of 3,5-disubstituted and polysubstituted phenols from acyclic precursors.
作者信息
Qian Jinlong, Yi Wenbin, Huang Xin, Miao Yongbo, Zhang Junkai, Cai Chun, Zhang Wei
机构信息
School of Chemical Engineering, Nanjing University of Science and Technology , Nanjing 210094, China.
出版信息
Org Lett. 2015 Mar 6;17(5):1090-3. doi: 10.1021/ol503615n. Epub 2015 Feb 12.
PMID:25675098
Abstract
A new strategy for the synthesis of 3,5-disubstituted phenols is established through one-pot Robinson annulation of α,β-unsaturated ketones with α-fluoro-β-ketoesters followed by in situ dehydrofluorination and tautomerization. This method has been extended to the synthesis of polysubstituted phenols and applied in the preparation of biologically active compounds.
摘要
通过α,β-不饱和酮与α-氟-β-酮酯的一锅法罗宾逊缩环反应，随后进行原位脱氟化氢和互变异构化，建立了一种合成3,5-二取代苯酚的新策略。该方法已扩展到多取代苯酚的合成，并应用于生物活性化合物的制备。
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