Andreeva P, Savova D, Konovalova M, Unakova M, Shterev A
Akush Ginekol (Sofiia). 2014;53(7):9-12.
Fungal colpitis is the most common inflammatory disease of the vagina, whose proportion in the different groups of the patients ranges from 30% to 60%. The major cause is genus Candida. In 80% to 95% of the cases the reason is Candida albicans species and in 10% to 20%--the representatives of the species Candida Non-albicans. One problem that arises in this genital infection is the insufficient effectiveness of the drug treatment in many of the cases.
MATERIALS, METHODS AND RESULTS: This study is a prospective and monitors 40 non-pregnant women, accounting therapeutic effect of Itraconazol in fungal colpitis. Patients had administered treatment with Itraconazol 2 x 200 mg/1 day, per oral. Microbiological testing was performed prior to the treatment and 2 to 4 weeks after completion of the therapy. We found C. albicans in 75% of the cases and in 25%--C. non-albicans (C. glabrata, C. kefyr, C. krusei, C. famata). In the group of C. albicans, good therapeutic efficiency was observed in 93.3% of the cases, while in patients with C. non-albicans it was in 80% of the cases.
Itraconazol showed sufficiently high therapeutic effect for patients with fungal colpitis, it proved to be suitable for patients with Candida albicans and also in the cases with Candida non-albicans.
霉菌性阴道炎是最常见的阴道炎症性疾病，在不同患者群体中的占比为30%至60%。主要病因是念珠菌属。在80%至95%的病例中病因是白色念珠菌，在10%至20%的病例中是非白色念珠菌属的代表菌种。这种生殖器感染中出现的一个问题是，在许多病例中药物治疗效果不佳。
材料、方法与结果：本研究是一项前瞻性研究，监测了40名非孕女性，评估伊曲康唑治疗霉菌性阴道炎的疗效。患者口服伊曲康唑，剂量为每日2次，每次200毫克。在治疗前及治疗结束后2至4周进行微生物检测。我们发现75%的病例为白色念珠菌感染，25%为非白色念珠菌感染（光滑念珠菌、克柔念珠菌、克鲁斯念珠菌、季也蒙念珠菌）。在白色念珠菌感染组中，93.3%的病例治疗效果良好，而在非白色念珠菌感染患者中，这一比例为80%。
伊曲康唑对霉菌性阴道炎患者显示出足够高的治疗效果，被证明适用于白色念珠菌感染患者以及非白色念珠菌感染的病例。
