Suzuki K, Nakata S, Tagaya M, Yasuma F, Moral S, Miyao E, Tsuiki S, Nakashima T
B-ENT. 2014;10(3):185-91.
Predictors of treatment outcome of oral appliances (OAs) in patients with obstructive sleep apnoea syndrome (OSAS) are not known. There is a pressing need for simple, clinically useful tools to predict treatment outcome. This study aimed to identify predictors of successful OA therapy for OSAS, including evaluation of pharyngeal morphology, which can be measured during routine examination by an otorhinolaryngologist.
This was a prospective study of 26 OSAS patients treated with OAs. A favourable outcome was obtained in 14 patients (responders) but not in 12 patients (nonresponders). The baseline patient characteristics and polysomnography and rhinopharyngeal findings were analysed.
Body mass index (BMI) was significantly lower in responders versus nonresponders (23.6 ± 2.8 vs. 27.9 ± 4.7 kg/m2; p < 0.05). Pharyngeal morphology, age, sex and nasal resistance did not differ between the groups. Multiple regression analysis showed that BMI was a significant predictor of improvement in the apnoea/hypopnoea index after OA treatment (p < 0.05).
Here we demonstrated that BMI is a favourable predictor of OA treatment outcome in OSAS patients. Among the OSAS patients, responders had wider retroglossal spaces than nonresponders.
阻塞性睡眠呼吸暂停综合征（OSAS）患者口腔矫治器（OA）治疗效果的预测因素尚不清楚。迫切需要简单且临床实用的工具来预测治疗效果。本研究旨在确定OSAS患者OA治疗成功的预测因素，包括评估咽形态，这可在耳鼻喉科医生的常规检查中进行测量。
这是一项对26例接受OA治疗的OSAS患者的前瞻性研究。14例患者（反应者）获得了良好的治疗效果，而12例患者（无反应者）则未获得。分析了患者的基线特征、多导睡眠图和鼻咽喉检查结果。
反应者的体重指数（BMI）显著低于无反应者（23.6±2.8 vs. 27.9±4.7 kg/m2；p<0.05）。两组之间的咽形态、年龄、性别和鼻阻力无差异。多元回归分析表明，BMI是OA治疗后呼吸暂停/低通气指数改善的显著预测因素（p<0.05）。
我们在此证明，BMI是OSAS患者OA治疗效果的有利预测因素。在OSAS患者中，反应者的舌后间隙比无反应者更宽。
