Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; and.
Atlanta Veterans Affairs Health Care System, Decatur, Georgia.
Am J Respir Cell Mol Biol. 2020 Aug;63(2):144-151. doi: 10.1165/rcmb.2019-0241TR.
The incidence and prevalence of nontuberculous mycobacteria (NTM) lung disease is rising worldwide and accounts for most clinical cases of NTM disease. NTM infections occur in both immunocompetent and immunocompromised hosts. Macrophages are the primary host cells that initiate an immune response to NTM. Defining the molecular events that govern the control of infection within macrophages is fundamental to understanding the pathogenesis of NTM disease. Here, we review key macrophage host signaling pathways that contribute to the host immune response to pulmonary NTM infections. In this review, we focus primarily on NTM that are known to cause lung disease, including , , and .
非结核分枝杆菌（NTM）肺病的发病率和患病率在全球范围内呈上升趋势，占 NTM 疾病的大多数临床病例。NTM 感染发生在免疫功能正常和免疫功能低下的宿主中。巨噬细胞是引发针对 NTM 免疫反应的主要宿主细胞。定义控制巨噬细胞内感染的分子事件对于理解 NTM 疾病的发病机制至关重要。在这里，我们回顾了有助于宿主对肺部 NTM 感染产生免疫反应的关键巨噬细胞宿主信号通路。在本综述中，我们主要关注已知会导致肺病的 NTM，包括 、 、和 。
