Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Metabolism. 2015 Apr;64(4):476-81. doi: 10.1016/j.metabol.2015.01.007. Epub 2015 Jan 22.
Gut microbiota remains a very interesting, yet largely unexplored ecosystem inside the human organism. The importance of this ecosystem for the physiology and the pathophysiology of the organism is being slowly unraveled. Recent studies reveal a connection between intestinal microbiota and atherosclerosis development. It seems that alterations in the function and composition of this bacterial population lead through complex mechanisms to a high risk for atherosclerosis. Although these mechanisms remain largely unknown, published studies show that microbiota can lead to atherosclerosis either by augmenting known risk factors or via other, more "direct" mechanisms. This review article summarizes the available literature regarding this matter.
肠道微生物群仍然是人体内部一个非常有趣但在很大程度上尚未被探索的生态系统。这个生态系统对机体的生理学和病理生理学的重要性正在被慢慢揭示。最近的研究揭示了肠道微生物群与动脉粥样硬化发展之间的联系。似乎这种细菌群体的功能和组成的改变通过复杂的机制导致了动脉粥样硬化的高风险。尽管这些机制在很大程度上尚不清楚，但已发表的研究表明，微生物群可以通过增强已知的危险因素或通过其他更“直接”的机制导致动脉粥样硬化。本文综述了关于这一问题的现有文献。
