Logan C, Willard H F, Rommens J M, Joyner A L
Division of Molecular and Developmental Biology, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada.
Genomics. 1989 Feb;4(2):206-9. doi: 10.1016/0888-7543(89)90301-7.
The human homologs of the mouse homeo box-containing genes, En-1 and En-2, which show homology to the Drosophila engrailed gene, have been isolated. The human EN1 gene was mapped to chromosome 2 by analysis of mouse-human somatic cell hybrids. The human EN2 gene was localized to chromosome 7, 7q32-7qter, by analysis of rodent-human somatic cell hybrids and cell lines carrying portions of chromosome 7.
已分离出与果蝇分节基因具有同源性的小鼠含同源异型框基因En-1和En-2的人类同源基因。通过对小鼠-人类体细胞杂种的分析，将人类EN1基因定位到2号染色体。通过对啮齿动物-人类体细胞杂种以及携带7号染色体部分片段的细胞系的分析，将人类EN2基因定位到7号染色体7q32-7qter区域。
