Devroey P, Palermo G, Bourgain C, Van Waesberghe L, Smitz J, Van Steirteghem A C
Centre for Reproductive Medicine, Academisch Ziekenhuis, Vrije Universiteit Brussel, Belgium.
Int J Fertil. 1989 May-Jun;34(3):188-93.
Forty-four women with absent ovaries who were referred to our centre for oocyte donation were treated with oestradiol valerate and natural progesterone. Serum concentrations and endometrial changes were evaluated on day 21 of stimulated luteal phases after the daily administration of 100 mg of natural progesterone in oil injected intramuscularly or after the ingestion of 300 mg of micronized progesterone or after vaginal administration of 300 mg or 600 mg micronized progesterone, respectively. Endometrial tissue did not show evidence of an adequate secretory pattern after orally administered progesterone. However, after intramuscular injection of 100 mg of natural progesterone and after the vaginal administration of 300 to 600 mg of micronized progesterone, the histologic and electron microscopic pictures were similar in all treatment groups and were close to the expected day 21 of the cycle. Serum levels of progesterone after intramuscular injection were five times higher than after vaginal administration.
44名因卵巢缺失而转诊至我们中心接受卵母细胞捐赠的女性，接受了戊酸雌二醇和天然孕酮治疗。在黄体期刺激的第21天，分别在每日肌肉注射100mg天然油剂孕酮后、或口服300mg微粉化孕酮后、或阴道给予300mg或600mg微粉化孕酮后，评估血清浓度和子宫内膜变化。口服孕酮后，子宫内膜组织未显示出充分的分泌模式证据。然而，在肌肉注射100mg天然孕酮以及阴道给予300至600mg微粉化孕酮后，所有治疗组的组织学和电子显微镜图像相似，且接近周期第21天的预期情况。肌肉注射后孕酮的血清水平比阴道给药后高五倍。
