Qi Nan Wu, Ling Zhang, Bing Chen
The First Affiliated Hospital of the Third Military Medical University, Endocrine Department , Chongqing, Post number: 400038 , China
Expert Opin Ther Targets. 2015 Jun;19(6):849-64. doi: 10.1517/14728222.2015.1016500. Epub 2015 Feb 13.
The telomere-telomerase system plays an important role in the pathogenesis and disease progression of diabetes mellitus as well as in its vascular complications. Recent studies suggest that telomere shortening and abnormal telomerase activity occur in patients with diabetes mellitus, and targeting the telomere-telomerase system has become a prospective treatment for diabetes mellitus and its vascular complications. This review highlights the significance of the telomere-telomerase system and supports its role as a possible therapeutic target for patients with diabetes mellitus and its vascular complications Areas covered: This review covers the advances in understanding the telomere-telomerase system over the last 30 years and its significance in diabetes mellitus. In addition, it provides knowledge regarding the significance of the telomere-telomerase system in diabetes mellitus and its vascular complications as well as its role and mechanisms in oxidative stress, cell therapy and antioxidant activity Expert opinion: The telomere-telomerase system may be a potential therapeutic target that can protect against DNA damage and apoptosis in patients with diabetes mellitus and its vascular complications. DNA damage and apoptosis are associated with oxidative stress and are involved in the dysfunction of pancreatic β cells, insulin resistance, and its vascular complications. Abnormalities in the telomere-telomerase system may be associated with diabetes mellitus and its vascular complications. Therapies targeting telomere-telomerase system, telomerase reverse transcriptase transfection and alterative telomere lengthening must be identified before gene therapy can commence.
端粒-端粒酶系统在糖尿病及其血管并发症的发病机制和疾病进展中起着重要作用。最近的研究表明，糖尿病患者存在端粒缩短和端粒酶活性异常的情况，针对端粒-端粒酶系统已成为糖尿病及其血管并发症的一种前瞻性治疗方法。本综述强调了端粒-端粒酶系统的重要性，并支持其作为糖尿病及其血管并发症患者可能的治疗靶点的作用。涵盖领域：本综述涵盖了过去30年中对端粒-端粒酶系统的认识进展及其在糖尿病中的意义。此外，它提供了有关端粒-端粒酶系统在糖尿病及其血管并发症中的意义、其在氧化应激、细胞治疗和抗氧化活性中的作用及机制的知识。专家观点：端粒-端粒酶系统可能是一个潜在的治疗靶点，可以保护糖尿病及其血管并发症患者免受DNA损伤和细胞凋亡。DNA损伤和细胞凋亡与氧化应激相关，并参与胰腺β细胞功能障碍、胰岛素抵抗及其血管并发症。端粒-端粒酶系统异常可能与糖尿病及其血管并发症有关。在基因治疗开始之前，必须确定针对端粒-端粒酶系统的疗法、端粒酶逆转录酶转染和替代端粒延长方法。
