Dessinioti Clio, Katsambas Andreas
Department of Dermatology, Andreas Syggros Hospital, University of Athens, Athens, Greece 5, Dragoumi str, Athens, 16121, Greece.
Department of Dermatology, Andreas Syggros Hospital, University of Athens, Athens, Greece 5, Dragoumi str, Athens, 16121, Greece.
Clin Dermatol. 2017 Mar-Apr;35(2):163-167. doi: 10.1016/j.clindermatol.2016.10.008. Epub 2016 Oct 27.
The human commensal bacterium Propionibacterium acnes (P. acnes) resides in the pilosebaceous duct of the skin. It has been long implicated in the pathogenesis of acne, although its exact role in the development of inflammatory acne lesions and in the formation of the microcomedo in the early stages of acne remains controversial. The worldwide prevalence of antibiotic-resistant P. acnes is increasing, with rates varying in different parts of the world. The reason for the difference in the antibiotic resistance patterns of P. acnes among different countries is not clear, although it may be attributed to different antibiotic prescribing habits, concomitant use of topical agents (retinoids, benzoyl peroxide, or other antibiotics), varying methods of bacterial sampling, or even different P. acnes populations. Although the relative abundances of P. acnes may be similar among patients with acne and individuals without acne, P. acnes populations and the presence of P. acnes biofilms differ, with different potential virulence properties and antimicrobial resistance patterns. Implications of the use of antibiotics and of antimicrobial resistance in patients with acne include the decreased efficacy of antibiotic treatments for acne, and the possible emergence of other resistant bacterial species via selective pressure by antibiotic use.
人共生菌痤疮丙酸杆菌（P. acnes）存在于皮肤的毛囊皮脂腺导管中。长期以来，它一直被认为与痤疮的发病机制有关，尽管其在炎性痤疮皮损发展以及痤疮早期微粉刺形成中的确切作用仍存在争议。全球范围内耐抗生素痤疮丙酸杆菌的患病率正在上升，不同地区的发生率有所不同。不同国家痤疮丙酸杆菌抗生素耐药模式存在差异的原因尚不清楚，尽管这可能归因于不同的抗生素处方习惯、局部用药（维甲酸、过氧化苯甲酰或其他抗生素）的联合使用、不同的细菌采样方法，甚至不同的痤疮丙酸杆菌菌群。虽然痤疮患者和非痤疮个体中痤疮丙酸杆菌的相对丰度可能相似，但痤疮丙酸杆菌菌群以及痤疮丙酸杆菌生物膜的存在有所不同，具有不同的潜在毒力特性和抗菌耐药模式。痤疮患者使用抗生素和抗菌耐药性的影响包括抗生素治疗痤疮的疗效降低，以及通过抗生素使用产生的选择性压力可能出现其他耐药细菌种类。
