早产儿侵袭性念珠菌病的流行病学与诊断
The epidemiology and diagnosis of invasive candidiasis among premature infants.
作者信息
Kelly Matthew S, Benjamin Daniel K, Smith P Brian
机构信息
Department of Pediatrics, Duke University, Box 3499, Durham, NC 27710, USA; Duke Clinical Research Institute, PO Box 17969, Durham, NC 27705, USA.
Department of Pediatrics, Duke University, Box 3499, Durham, NC 27710, USA; Duke Clinical Research Institute, PO Box 17969, Durham, NC 27705, USA.
出版信息
Clin Perinatol. 2015 Mar;42(1):105-17, viii-ix. doi: 10.1016/j.clp.2014.10.008. Epub 2014 Nov 28.
Abstract
Invasive candidiasis is a leading infectious cause of morbidity and mortality in premature infants. Improved recognition of modifiable risk factors and antifungal prophylaxis has contributed to the recent decline in the incidence of this infection among infants. Invasive candidiasis typically occurs in the first 6 weeks of life and presents with nonspecific signs of sepsis. Definitive diagnosis relies on the growth of Candida in blood culture or cultures from other normally sterile sites, but this may identify fewer than half of cases. Improved diagnostics are needed to guide the initiation of antifungal therapy in premature infants.
摘要
侵袭性念珠菌病是早产儿发病和死亡的主要感染原因。对可改变的危险因素的更好识别以及抗真菌预防措施，促使近期婴儿中这种感染的发病率有所下降。侵袭性念珠菌病通常发生在出生后的前6周，表现为败血症的非特异性体征。确诊依赖于念珠菌在血培养或其他通常无菌部位的培养物中生长，但这可能只能识别不到一半的病例。需要改进诊断方法来指导早产儿抗真菌治疗的启动。
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