Nat Cell Biol. 2015 Jan;17(1):1-3. doi: 10.1038/ncb3089.
The class III phosphoinositide 3-kinase VPS34 regulates autophagosome formation. Three groups have developed VPS34 inhibitors and shown their utility in investigating and defining autophagic processes.
III 类磷酸肌醇 3-激酶 VPS34 调控自噬体的形成。三组研究人员已经开发出 VPS34 抑制剂,并展示了它们在研究和定义自噬过程中的应用。