Department of Chemical Engineering, Northeastern University , Boston, Massachusetts 02115, United States.
ACS Appl Mater Interfaces. 2015 Mar 4;7(8):4518-24. doi: 10.1021/am506866a. Epub 2015 Feb 23.
A challenge of X-ray radiation therapy is that high dose X-rays at therapeutic conditions damage normal cells. This paper describes the use of gold nanoparticle-loaded multilayer microdisks to enhance X-ray radiation therapy, where each microdisk contains over 10(5) radiosensitizing nanoparticles. The microdisks are attached on cell membranes through electrostatic interaction. Upon X-ray irradiation, more photoelectrons and Auger electrons are generated in the vicinity of the nanoparticles, which cause water ionization and lead to the formation of free radicals that damage the DNA of adjacent cancer cells. By attaching a large amount of gold nanoparticles on cancer cells, the total X-ray dose required for DNA damage and cell killing can be reduced. Due to their controllable structure and composition, multilayer microdisks can be a viable choice for enhanced radiation therapy with nanoparticles.
X 射线放射治疗的一个挑战是，治疗条件下的高剂量 X 射线会损伤正常细胞。本文描述了使用负载金纳米颗粒的多层微盘来增强 X 射线放射治疗，其中每个微盘包含超过 10(5)个放射增敏纳米颗粒。微盘通过静电相互作用附着在细胞膜上。在 X 射线照射下，纳米颗粒附近会产生更多的光电子和俄歇电子，导致水的离子化，并形成自由基，破坏相邻癌细胞的 DNA。通过将大量的金纳米颗粒附着在癌细胞上，可以减少破坏 DNA 和杀死细胞所需的总 X 射线剂量。由于其可控的结构和组成，多层微盘可以成为一种可行的选择，用于具有纳米颗粒的增强放射治疗。
