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压力性尿失禁治疗的成本效用

Cost utility of the treatment of stress urinary incontinence.

作者信息

Von Bargen Emily, Patterson Danielle

机构信息

From the *Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Mount Auburn Hospital/Beth Israel Deaconess Medical Center, Cambridge; and †Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, University of Massachusetts Memorial Medical Center, Worcester, MA.

出版信息

Female Pelvic Med Reconstr Surg. 2015 May-Jun;21(3):150-3. doi: 10.1097/SPV.0000000000000159.

Abstract

OBJECTIVE

We sought to investigate the cost utility of nonsurgical versus surgical treatments for stress urinary incontinence (SUI).

METHODS

A decision analysis model was created to compare nonsurgical and surgical treatment options for women with SUI. Decision paths included conservative management, pelvic floor physical therapy (pelvic floor muscle training [PFMT]), PFMT with electrical stimulation, incontinence pessary, and surgical treatment. A Markov model cohort analysis was performed with a cycle length of 1 year starting at age 45 years with a lifetime horizon. Probabilities, success rates, and utilities were obtained from the literature when available or by expert opinion. Cost-utility analysis was performed using US recommendations from a societal perspective. Cost data were obtained from Medicare reimbursement in 2012 US dollars.

RESULTS

Incontinence pessary was the most cost-effective treatment option with a cost of $11,411 for 18.9 quality-adjusted life years. At a willingness to pay (WTP) threshold of $50,000, incontinence pessary remained the most cost-effective treatment option. At a WTP threshold of $60,000, surgery became the most cost-effective treatment option. The PFMT and PFMT with electrical stimulation were dominated at any WTP threshold.

CONCLUSIONS

Surgical correction is likely the most cost-effective treatment option for young healthy women with SUI. Results are driven by the high success rate of minimally invasive slings. More studies are needed to define utility values for heath states experienced by women with SUI. This will enhance our ability to develop more accurate cost-utility models and offer the best treatment for women affected by incontinence.

摘要

目的

我们试图研究压力性尿失禁(SUI)非手术治疗与手术治疗的成本效益。

方法

创建一个决策分析模型,以比较SUI女性的非手术和手术治疗方案。决策路径包括保守治疗、盆底物理治疗(盆底肌肉训练[PFMT])、电刺激下的PFMT、失禁子宫托和手术治疗。从45岁开始进行马尔可夫模型队列分析,周期长度为1年,直至终身。概率、成功率和效用值在有可用文献时获取,或通过专家意见确定。从社会角度采用美国的建议进行成本效益分析。成本数据以2012年美元的医疗保险报销费用为准。

结果

失禁子宫托是最具成本效益的治疗方案,每获得18.9个质量调整生命年的成本为11,411美元。在支付意愿(WTP)阈值为50,000美元时,失禁子宫托仍是最具成本效益的治疗方案。在WTP阈值为60,000美元时,手术成为最具成本效益的治疗方案。在任何WTP阈值下,PFMT和电刺激下的PFMT都处于劣势。

结论

对于年轻健康的SUI女性,手术矫正可能是最具成本效益的治疗方案。结果受微创吊带术高成功率的驱动。需要更多研究来确定SUI女性所经历健康状态的效用值。这将增强我们开发更准确成本效益模型的能力,并为受尿失禁影响的女性提供最佳治疗。

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