Zhu Dan, Yang Da-Yong, Guo Yuan-Yuan, Zheng Yan-Fei, Li Jun-Lian, Wang Bin, Tao Yong, Jonas Jost B
Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Department of Ophthalmology, People's Hospital, Peking University, Beijing, China.
PLoS One. 2015 Feb 13;10(2):e0117777. doi: 10.1371/journal.pone.0117777. eCollection 2015.
To assess associations between the aqueous humour concentration of interleukin IL-1β, IL-6, IL-8, IL-10 and IL-12p, tumor necrosis factor α (TNF-α) and vascular endothelial growth factor (VEGF) and axial length in eyes with cataract.
The hospital-based investigation included patients who underwent cataract surgery between March 2014 and April 2014. Using aqueous humour collected at the start of cataract surgery, the interleukins IL-1β, IL-6, IL-8, IL-10 and IL-12p, TNF-α and VEGF were examined using a cytometric bead array. Axial length was determined by partial coherence laser interferometry (IOL Master).
The study included 33 patients with cataract (33 eyes) with a mean age of 69.2±10.8 years (range: 50-87 years) and a mean axial length of 24.7±1.9 mm (range: 22.6-31.5 mm). Lower aqueous concentration of VEGF was significantly associated with longer axial length (VEGF concentration (pg/mL) = -5.12 x Axial Length (mm) + 163; correlation coefficient r = -0.41; P<0.001) and more myopic refractive error (VEGF concentration (pg/mL) = 1.27 x spherical equivalent (diopters) + 44.8; r = 0.383; P = 0.002). The aqueous concentrations of all other substances were not significantly (all P>0.10) associated with axial length or refractive error.
Higher intravitreal concentrations of VEGF were measured in eyes with a longer axial length, while the intraocular concentrations of IL-1β, IL-6, IL-8, IL-10, IL-12p and TNF-α were not correlated with axial length. The lower concentration of VEGF in axially elongated eyes may be one of the reasons for the lower prevalence of age-related macular degeneration and diabetic retinopathy in myopic eyes.
评估白内障患者房水中白细胞介素IL-1β、IL-6、IL-8、IL-10和IL-12p、肿瘤坏死因子α（TNF-α）及血管内皮生长因子（VEGF）的浓度与眼轴长度之间的关联。
这项基于医院的调查纳入了2014年3月至2014年4月期间接受白内障手术的患者。利用白内障手术开始时采集的房水，采用细胞计数珠阵列检测白细胞介素IL-1β、IL-6、IL-8、IL-10和IL-12p、TNF-α及VEGF。通过部分相干激光干涉测量法（IOL Master）测定眼轴长度。
该研究纳入了33例白内障患者（33只眼），平均年龄为69.2±10.8岁（范围：50 - 87岁），平均眼轴长度为24.7±1.9 mm（范围：22.6 - 31.5 mm）。房水中VEGF浓度较低与眼轴长度较长显著相关（VEGF浓度（pg/mL）= -5.12×眼轴长度（mm）+ 163；相关系数r = -0.41；P<0.001），且与近视屈光不正程度更高相关（VEGF浓度（pg/mL）= 1.27×等效球镜度（屈光度）+ 44.8；r = 0.383；P = 0.002）。所有其他物质的房水浓度与眼轴长度或屈光不正均无显著关联（所有P>0.10）。
眼轴长度较长的眼中玻璃体内VEGF浓度较高，而IL-1β、IL-6、IL-8、IL-10、IL-12p和TNF-α的眼内浓度与眼轴长度无关。眼轴伸长的眼中VEGF浓度较低可能是近视眼年龄相关性黄斑变性和糖尿病视网膜病变患病率较低的原因之一。
