Van Swearingen Amanda Ed, Siegel Marni B, Anders Carey K
Breast Cancer Res. 2014 May 6;16(3):304. doi: 10.1186/bcr3651.
Brain metastases remain a significant challenge in the treatment of breast cancer patients due to the unique environment posed by the central nervous system. A better understanding of the biology of breast cancer cells that have metastasized to the brain is required to develop improved therapies. A recent Proceedings of the National Academy of Sciences article demonstrates that breast cancer cells in the brain microenvironment express γ-aminobutyric acid (GABA)-related genes, enabling them to utilize GABA as an oncometabolite, thus gaining a proliferative advantage. In this viewpoint, we highlight these findings and their potential impact on the treatment of breast cancer brain metastases.
由于中枢神经系统所构成的独特环境，脑转移瘤仍是乳腺癌患者治疗中的一项重大挑战。为了开发出更有效的治疗方法，需要更好地了解已转移至脑部的乳腺癌细胞的生物学特性。美国国家科学院近期发表的一篇文章表明，处于脑微环境中的乳腺癌细胞会表达与γ-氨基丁酸（GABA）相关的基因，使其能够将GABA用作肿瘤代谢物，从而获得增殖优势。在本文观点中，我们强调了这些发现及其对乳腺癌脑转移治疗的潜在影响。
