人子宫中γ-氨基丁酸（GABA）水平及GABA结合的孕期变化

Gestational changes of GABA levels and GABA binding in the human uterus.

作者信息

Erdö S L, Villányi P, László A

机构信息

Department of Anatomy, Georg-August-University, Göttingen, FRG.

出版信息

Life Sci. 1989;44(26):2009-14. doi: 10.1016/0024-3205(89)90346-9.

DOI:10.1016/0024-3205(89)90346-9

PMID:2545985

Abstract

The concentrations of gamma-aminobutyric acid (GABA), the activities of L-glutamate decarboxylase and GABA-transaminase, and the nature of the sodium-independent binding of GABA were examined in uterine tissue pieces obtained surgically from pregnant and non-pregnant women. GABA concentrations were reduced, while the activity of GABA-transaminase and the specific binding of [3H]GABA significantly increased in specimens from pregnant subjects. These findings suggest some gestation-related functional role for the GABA system in the human uterus.

摘要

对从孕妇和非孕妇手术获取的子宫组织块中γ-氨基丁酸（GABA）的浓度、L-谷氨酸脱羧酶和GABA转氨酶的活性以及GABA非钠依赖性结合的性质进行了检测。孕妇标本中GABA浓度降低，而GABA转氨酶活性和[3H]GABA的特异性结合显著增加。这些发现提示GABA系统在人类子宫中具有一些与妊娠相关的功能作用。