乳腺癌患者脑转移疾病之谜：患者分层、疾病预测及靶向预防有望得到改善？
Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon?
作者信息
Polivka Jiri, Kralickova Milena, Polivka Jiri, Kaiser Christina, Kuhn Walther, Golubnitschaja Olga
机构信息
Department of Histology and Embryology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic.
Biomedical Centre, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic.
出版信息
EPMA J. 2017 Mar 13;8(2):119-127. doi: 10.1007/s13167-017-0087-5. eCollection 2017 Jun.
Abstract
The breast cancer (BC) diagnosis currently experiences the epidemic evolution with more than half of million deaths each year. Despite screening programmes applied and treatments available, breast cancer patients frequently develop distant metastases. The brain is one of the predominant sites of the metastatic spread recorded for more than 20% of BC patients, in contrast to the general population, where brain tumours are rarely diagnosed. Although highly clinically relevant, the brain tumour mystery in the cohort of breast cancer patients has not been yet adequately explained. This review summarises currently available information on the risk factors predicting brain metastases in BC patients to motivate the relevant scientific areas to explore the data/facts available and elucidate disease-specific mechanisms that are of a great clinical utility.
摘要
目前，乳腺癌（BC）诊断呈流行趋势，每年有超过50万人死亡。尽管实施了筛查计划并提供了治疗方法，但乳腺癌患者仍经常发生远处转移。大脑是超过20%的BC患者发生转移扩散的主要部位之一，而在普通人群中，脑肿瘤很少被诊断出来。尽管具有高度临床相关性，但乳腺癌患者队列中的脑肿瘤之谜尚未得到充分解释。本综述总结了目前关于预测BC患者脑转移风险因素的可用信息，以激励相关科学领域探索现有数据/事实，并阐明具有重大临床应用价值的疾病特异性机制。
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