Pollak Shaul, Omer Bendori Shira, Eldar Avigdor
Department of Molecular Microbiology and Biotechnology, Tel Aviv University, 69978, Tel Aviv, Israel.
Curr Genet. 2015 Nov;61(4):493-6. doi: 10.1007/s00294-015-0479-9. Epub 2015 Feb 14.
Microorganisms adapt to the lab environment by eliminating unnecessary genetic systems. In Bacillus subtilis, such adaptation resulted in the lab strain being unable to form complex, matrix-associated structures known as biofilms. We recently showed that the ancestor of the lab strain, which is considered by the research community to be a stereotypical 'wild' strain, carries an atypical mutation in the RapP-PhrP quorum-sensing system. We have found that this mutation has profound effects on the biofilm phenotype of the ancestral strain. Here we discuss these recent findings and present more data that focuses on the lessons that can be learned from this work on the domestication of microorganisms.
微生物通过消除不必要的遗传系统来适应实验室环境。在枯草芽孢杆菌中，这种适应导致实验室菌株无法形成称为生物膜的复杂的、与基质相关的结构。我们最近发现，该实验室菌株的祖先，被研究界认为是典型的“野生”菌株，在RapP-PhrP群体感应系统中携带一个非典型突变。我们发现这个突变对祖先菌株的生物膜表型有深远影响。在这里，我们讨论这些最新发现，并提供更多数据，重点关注从这项关于微生物驯化的研究中可以学到的经验教训。
