Kiistala U, Paavonen T, Saarelainen I, Aronen H, Asko-Seljavaara S, Kariniemi A L, Ingervo L, Niemitalo S
Central Military Hospital, Helsinki, Finland.
Acta Derm Venereol. 1989;69(4):284-7.
Creatine kinase (CK) isoenzyme, CK-BB, known as the brain fraction, is not normally present in serum but predominates in several normal and malignant tissues and body fluids. We recently reported increased CK-BB levels in suction blister fluid. In the present study the cellular origin of the enzyme in skin was studied from homogenates of blister top epidermis and blister base dermis as well as from homogenates of split skin dermatome shavings and isolated keratinocytes. The CK-BB in human skin was derived almost exclusively from the epidermis. Enzyme determinations from various spontaneous bullae suggest that all types of skin blisters initially contain high CK-BB levels.
肌酸激酶（CK）同工酶CK - BB，即所谓的脑型同工酶，正常情况下不存在于血清中，但在几种正常组织、恶性组织及体液中占主导地位。我们最近报道了抽吸水疱液中CK - BB水平升高。在本研究中，从水疱顶部表皮和水疱底部真皮的匀浆以及皮肤切片刨花和分离的角质形成细胞的匀浆中研究了皮肤中该酶的细胞来源。人皮肤中的CK - BB几乎完全来源于表皮。对各种自发性水疱的酶测定表明，所有类型的皮肤水疱最初都含有高浓度的CK - BB。
