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植物核被膜与基因表达调控。

The plant nuclear envelope and regulation of gene expression.

机构信息

University of Liverpool, Institute of Integrative Biology, Crown Street, University of Liverpool, Liverpool L69 7ZB, UK

出版信息

J Exp Bot. 2015 Mar;66(6):1673-85. doi: 10.1093/jxb/erv023. Epub 2015 Feb 13.

DOI:10.1093/jxb/erv023
PMID:25680795
Abstract

The nuclear envelope (NE) separates the key mechanisms of transcription and translation, and as such is a critical control point in all eukaryotic cells. In plants, the proteins of the NE influence a number of processes including the control of nucleo-cytoplasmic transport of RNA and protein, chromatin localization to the nuclear periphery, and direct chromatin binding by members of the nuclear pore complex (NPC). In this review I attempt to bring these roles under the umbrella of their effect on gene expression, even though the complex nature of this cellular environment means there is considerable overlap of effects. Although the volume of research in plant cells has greatly improved over recent years, it is clear that our understanding of how the components of the NE either directly or indirectly influence gene expression is still in its infancy.

摘要

核膜(NE)将转录和翻译的关键机制分隔开来,因此是所有真核细胞的一个关键控制点。在植物中,NE 的蛋白质影响许多过程,包括 RNA 和蛋白质的核质转运的控制、染色质定位于核周、以及核孔复合体(NPC)成员的直接染色质结合。在这篇综述中,我试图将这些作用纳入它们对基因表达的影响之下,尽管细胞环境的复杂性意味着这些作用存在相当大的重叠。尽管近年来植物细胞的研究数量大大增加,但显然,我们对 NE 的成分如何直接或间接地影响基因表达的理解仍处于起步阶段。

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