Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, 100084, China.
Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
New Phytol. 2018 Jul;219(1):25-30. doi: 10.1111/nph.14756. Epub 2017 Aug 31.
Contents Summary 25 I Introduction 25 II. Structural organization of the NPC 26 III. The role of NPCs in immune signaling 26 IV. The role of NPCs in hormone signaling 28 V. Conclusions 29 Acknowledgements 29 References 29 SUMMARY: Nuclear pore complexes (NPCs) are fundamental components of the eukaryotic cell. They perforate the nuclear envelope and serve as highly selective transport gates that enable bi-directional macromolecule exchange between the nucleus and cytoplasm. Recent studies illustrate that the NPC is not a static structural channel but a flexible environment and strategic player during nuclear signaling. The constitutional and conformational dynamics of the NPC allow it to tailor nucleocytoplasmic transport activities and define specific signaling output in response to various cellular and environmental cues. In this Insight, we review the roles of NPC constituents in immune activation and hormone signaling in plants, and discuss the possible role of the NPC as a legitimate platform for regulating cell signaling.
内容摘要 25 I. 引言 25 II. NPC 的结构组织 26 III. NPC 在免疫信号中的作用 26 IV. NPC 在激素信号中的作用 28 V. 结论 29 致谢 29 参考文献 29 摘要：核孔复合体（NPC）是真核细胞的基本组成部分。它们贯穿核膜，充当高度选择性的运输门，使核质和细胞质之间的双向大分子交换成为可能。最近的研究表明，NPC 不是一个静态的结构通道，而是一个灵活的环境和核信号传递过程中的战略参与者。NPC 的组成和构象动力学使其能够调整核质转运活动，并根据各种细胞和环境线索定义特定的信号输出。在这篇观点文章中，我们回顾了 NPC 成分在植物免疫激活和激素信号中的作用，并讨论了 NPC 作为调节细胞信号的合法平台的可能作用。
