Brummond Neil R, Locke G Richard, Choung Rok Seon, Chang Joseph Y, Schleck Cathy D, Zinsmeister Alan R, Talley Nicholas J
Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Dig Dis Sci. 2015 Jul;60(7):2112-8. doi: 10.1007/s10620-015-3565-4. Epub 2015 Feb 14.
Irritable bowel syndrome (IBS) is common with prevalence reported between 10 and 20 %. IBS clusters in families but it is unknown whether this is explained by a common environment, genes, or both. If early-life factors are important, IBS might be expected to demonstrate a birth cohort phenomenon.
To investigate whether there is a birth cohort phenomenon for subjects with IBS.
Validated questionnaires were sent to a random sample of Olmsted County, Minnesota, residents who recorded gastrointestinal symptoms; IBS diagnosis was based on the modified Rome criteria. Birth cohorts were chosen a priori based on historical national trends in birth weights using 10-year increments. Logistic regression was used to develop odds ratios to assess the association of IBS with calendar period, birth cohort, age, gender, and somatic symptom score.
A total of 4,893 surveys were completed with an overall survey response rate of 58 %. The survey responders were between 25 and 94 years of age and 53 % were female. The overall prevalence of IBS was 16.2 % (95 % CI 15.3-17.4). The univariate association of IBS with birth cohort was significant (p < 0.001) as was the association adjusted for age and gender. The prevalence of IBS was highest for the birth cohort 1963-1972 with an odds ratio of 2.6 (95 % CI 0.97-7.0, p = 0.058).
Population-based data support a possible birth cohort phenomenon in IBS. If correct, early-life risk factors likely play a key role in the development of IBS.
肠易激综合征（IBS）很常见，报告的患病率在10%至20%之间。IBS在家族中聚集，但尚不清楚这是由共同环境、基因还是两者共同导致的。如果早期生活因素很重要，那么IBS可能会表现出出生队列现象。
研究IBS患者是否存在出生队列现象。
向明尼苏达州奥姆斯特德县记录有胃肠道症状的居民随机样本发送经过验证的问卷；IBS诊断基于改良的罗马标准。根据历史上全国出生体重趋势，以10年为增量预先选择出生队列。使用逻辑回归来计算比值比，以评估IBS与日历时间、出生队列、年龄、性别和躯体症状评分之间的关联。
共完成了4893份调查问卷，总体调查回复率为58%。调查对象年龄在25至94岁之间，53%为女性。IBS的总体患病率为16.2%（95%可信区间15.3 - 17.4）。IBS与出生队列的单变量关联显著（p < 0.001），经年龄和性别调整后的关联也显著。1963 - 1972年出生队列的IBS患病率最高，比值比为2.6（95%可信区间0.97 - 7.0，p = 0.058）。
基于人群的数据支持IBS可能存在出生队列现象。如果这一结论正确，那么早期生活风险因素可能在IBS的发病过程中起关键作用。
