Departamento de Medicina Preventiva y Salud Pública, Universidad Autónoma de Madrid/IdiPaz, and Ciber of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Obesity (Silver Spring). 2015 Apr;23(4):847-55. doi: 10.1002/oby.21013. Epub 2015 Feb 13.
To evaluate for the first time the longitudinal relationship between abdominal obesity and the onset of frailty.
Study based on results from two population-based cohorts, the Seniors-ENRICA, with 1801 individuals aged ≥60, and the Toledo Study for Healthy Ageing (TSHA), with 1289 participants ≥65 years. Incident frailty was assessed with the Fried criteria.
During 3.5 years of follow-up, 125 individuals with incident frailty in Seniors-ENRICA and 162 in TSHA were identified. After adjustment for the main confounders, the pooled odds ratio (pooled OR) for general obesity and risk of frailty was 1.73 (95% confidence interval [CI]: 1.18-2.28). Abdominal obesity was also associated with frailty (pooled OR: 1.67; 95% CI: 1.09-2.25). Compared with individuals with BMI <25 kg/m(2) and no abdominal obesity, the risk of frailty was highest among individuals with concurrent general and abdominal obesity (pooled OR: 2.55; 95% CI: 1.23-3.86). General obesity was associated with increased risk of exhaustion (pooled OR: 1.66; 95% CI: 1.11-2.21), low physical activity (pooled OR: 1.57; 95% CI: 1.08-2.05), and weakness (pooled OR: 1.63; 95% CI: 1.12-2.05). For abdominal obesity, results were in the same direction, although they showed statistical significance only for weakness (OR: 1.46; 95% CI: 1.11-1.80).
General and abdominal obesity are associated with incident frailty in the elderly.
首次评估腹型肥胖与虚弱发生之间的纵向关系。
该研究基于两项基于人群的队列研究结果，老年人 ENRICA 研究（Seniors-ENRICA）纳入 1801 名年龄≥60 岁的个体，托莱多健康老龄化研究（Toledo Study for Healthy Ageing，TSHA）纳入 1289 名年龄≥65 岁的参与者。使用 Fried 标准评估虚弱的发生情况。
在 Seniors-ENRICA 的 3.5 年随访期间，有 125 名个体发生了虚弱，在 TSHA 中有 162 名个体发生了虚弱。在调整了主要混杂因素后，普通肥胖与虚弱风险的合并比值比（pooled OR）为 1.73（95%置信区间[CI]：1.18-2.28）。腹型肥胖也与虚弱相关（pooled OR：1.67；95% CI：1.09-2.25）。与 BMI＜25 kg/m²且无腹型肥胖的个体相比，同时存在普通肥胖和腹型肥胖的个体虚弱风险最高（pooled OR：2.55；95% CI：1.23-3.86）。普通肥胖与易疲劳（pooled OR：1.66；95% CI：1.11-2.21）、低体力活动（pooled OR：1.57；95% CI：1.08-2.05）和虚弱（pooled OR：1.63；95% CI：1.12-2.05）风险增加相关。对于腹型肥胖，结果也是一致的，尽管仅在虚弱方面具有统计学意义（OR：1.46；95% CI：1.11-1.80）。
普通肥胖和腹型肥胖与老年人虚弱的发生有关。
