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闭塞性细支气管炎合并史蒂文斯-约翰逊综合征:一例报告

Bronchiolitis obliterans associated with Stevens-Johnson syndrome: a case report.

作者信息

Park Hyungchul, Ko Young Bo, Kwon Hyouk-Soo, Lim Chae-Man

机构信息

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Division of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

Yonsei Med J. 2015 Mar;56(2):578-81. doi: 10.3349/ymj.2015.56.2.578.

Abstract

We report a case of bronchiolitis obliterans associated with Stevens-Johnson syndrome. A 59-year-old man presented with respiratory distress that gradually worsened over 3 months. He had been diagnosed with Stevens-Johnson syndrome 3 months before admission. He had no history of previous airway disease. On physical examination, expiratory breathing sounds were not audible, and a chest X-ray revealed a hyperinflated lung. A pulmonary function test indicated a severe obstructive pattern. Computed tomography scans of inspiratory and expiratory phases of respiration showed oligemia and air trapping, and both were more prominent on expiration view than on inspiration view. The pathogenesis of bronchiolitis obliterans associated with Stevens-Johnson syndrome is largely unknown.

摘要

我们报告一例与史蒂文斯-约翰逊综合征相关的闭塞性细支气管炎病例。一名59岁男性出现呼吸窘迫,在3个月内逐渐加重。他在入院前3个月被诊断为史蒂文斯-约翰逊综合征。他既往无气道疾病史。体格检查时,呼气呼吸音不可闻,胸部X线显示肺过度充气。肺功能测试表明为严重阻塞性模式。呼吸吸气和呼气期的计算机断层扫描显示肺血减少和空气潴留,两者在呼气期比吸气期更明显。与史蒂文斯-约翰逊综合征相关的闭塞性细支气管炎的发病机制在很大程度上尚不清楚。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/4329375/69259d923a50/ymj-56-578-g001.jpg

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