Katagiri Fumihiko, Kotani Masato, Hirai Tsuyoshi, Kagawa Jiro
Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachioji 192-0392, Tokyo, Japan.
Asahina Shinryoujo, Nyufune 314-5, Okabecho, Fujieda, Shizuoka 421-1115, Japan; Department of Internal Medicine, Fujieda Municipal General Hospital, Surugadai 4-1-11, Fujieda, Shizuoka 426-8677, Japan.
Biochem Biophys Res Commun. 2015 Mar 13;458(3):663-666. doi: 10.1016/j.bbrc.2015.02.021. Epub 2015 Feb 12.
The kisspeptin (metastin) is an endogenous peptide, which regulates human reproduction by modulating gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin was detected in peripheral blood, although GnRH was not. Previously, we measured plasma kisspeptin levels in male healthy subjects and patients with hypogonadism using enzyme immunoassay (EIA) to elucidate a normal range in healthy males and clinical implications of kisspeptin in male hypogonadism. We suggested that the plasma kisspeptin levels were received feedback from testosterone. In this study, we focused female subjects and elucidated the relationship between menstrual cycle and plasma kisspeptin levels to understand kisspeptin-hypothalamic-pituitary-gonadal axis. We measured plasma kisspeptin levels in eight female volunteers. The plasma kisspeptin levels in female are significantly higher than those in male. There are no significant correlation between plasma kisspeptin levels and sexual hormones. We revealed that the kisspeptin might stimulate a start of menstruation as a trigger, and progress menstruation covered for weakened ovarian function. We suggest that kisspeptin may be closely related with menstrual cycle and that the measurement of plasma kisspeptin levels is useful for understanding of reproductive system.
亲吻素（又名 metastin）是一种内源性肽，它通过调节促性腺激素释放激素（GnRH）的分泌来调控人类生殖。尽管在周围血液中未检测到GnRH，但却检测到了亲吻素。此前，我们采用酶免疫测定法（EIA）测量了男性健康受试者和性腺功能减退患者血浆中的亲吻素水平，以阐明健康男性的正常范围以及亲吻素在男性性腺功能减退中的临床意义。我们认为血浆亲吻素水平受到睾酮的反馈调节。在本研究中，我们聚焦于女性受试者，阐明月经周期与血浆亲吻素水平之间的关系，以了解亲吻素 - 下丘脑 - 垂体 - 性腺轴。我们测量了8名女性志愿者血浆中的亲吻素水平。女性血浆亲吻素水平显著高于男性。血浆亲吻素水平与性激素之间无显著相关性。我们发现亲吻素可能作为一种触发因素刺激月经初潮，并在卵巢功能减弱时推动月经进程。我们认为亲吻素可能与月经周期密切相关，并且测量血浆亲吻素水平有助于了解生殖系统。
