Takla P G, Dakas C J
Welsh School of Pharmacy, University of Wales College of Cardiff, UK.
J Pharm Pharmacol. 1989 Apr;41(4):227-30. doi: 10.1111/j.2042-7158.1989.tb06440.x.
Infrared data determined for known polymorphic forms and some new derivatives of acetohexamide and related compounds support the view that acetohexamide polymorphs exhibit keto-enol tautomerism. They indicate that type A polymorphs exist in the enol form, probably stabilized by intramolecular bonding between an O-H and S = O group to form a six-membered ring. Type B polymorphs exist in the keto form with the urea carbonyl group intermolecularly bonded to a sulphonamide N-H. The new evidence disputes previous interpretations of the data.
为乙酰己脲及相关化合物的已知多晶型物和一些新衍生物测定的红外数据支持了这样一种观点，即乙酰己脲多晶型物表现出酮 - 烯醇互变异构现象。这些数据表明，A型多晶型物以烯醇形式存在，可能通过O - H与S = O基团之间的分子内键合形成六元环而得以稳定。B型多晶型物以酮形式存在，脲羰基通过分子间与磺酰胺N - H键合。新证据对以前的数据解释提出了质疑。
