药物纳米载体的可控药物释放
Controlled Drug Release from Pharmaceutical Nanocarriers.
作者信息
Lee Jinhyun Hannah, Yeo Yoon
机构信息
College of Pharmacy and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
College of Pharmacy and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA ; Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
出版信息
Chem Eng Sci. 2015 Mar 24;125:75-84. doi: 10.1016/j.ces.2014.08.046.
Nanocarriers providing spatiotemporal control of drug release contribute to reducing toxicity and improving therapeutic efficacy of a drug. On the other hand, nanocarriers face unique challenges in controlling drug release kinetics, due to the large surface area per volume ratio and the short diffusion distance. To develop nanocarriers with desirable release kinetics for target applications, it is important to understand the mechanisms by which a carrier retains and releases a drug, the effects of composition and morphology of the carrier on the drug release kinetics, and current techniques for preparation and modification of nanocarriers. This review provides an overview of drug release mechanisms and various nanocarriers with a specific emphasis on approaches to control the drug release kinetics.
能够实现药物释放时空控制的纳米载体有助于降低药物毒性并提高治疗效果。另一方面，由于纳米载体每单位体积的表面积大且扩散距离短，在控制药物释放动力学方面面临独特挑战。为开发适用于目标应用的具有理想释放动力学的纳米载体，了解载体保留和释放药物的机制、载体组成和形态对药物释放动力学的影响以及当前纳米载体的制备和改性技术非常重要。本综述概述了药物释放机制和各种纳米载体，特别强调了控制药物释放动力学的方法。
Zotero 插件