Dolatkhah Roya, Somi Mohammad Hossein, Bonyadi Mortaza Jabbarpour, Asvadi Kermani Iraj, Farassati Faris, Dastgiri Saeed
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cancer Epidemiol. 2015;2015:643020. doi: 10.1155/2015/643020. Epub 2015 Jan 15.
Purpose. The increasing incidence of colorectal cancer (CRC) in the past three decades in Iran has made it a major public health burden. This study aimed to report its epidemiologic features, molecular genetic aspects, survival, heredity, and screening pattern in Iran. Methods. A comprehensive literature review was conducted to identify the relevant published articles. We used medical subject headings, including colorectal cancer, molecular genetics, KRAS and BRAF mutations, screening, survival, epidemiologic study, and Iran. Results. Age standardized incidence rate of Iranian CRCs was 11.6 and 10.5 for men and women, respectively. Overall five-year survival rate was 41%, and the proportion of CRC among the younger age group was higher than that of western countries. Depending on ethnicity, geographical region, dietary, and genetic predisposition, mutation genes were considerably diverse and distinct among CRCs across Iran. The high occurrence of CRC in records of relatives of CRC patients showed that family history of CRC was more common among young CRCs. Conclusion. Appropriate screening strategies for CRC which is amenable to early detection through screening, especially in relatives of CRCs, should be considered as the first step in CRC screening programs.
目的。过去三十年来，伊朗结直肠癌（CRC）发病率不断上升，已成为一项重大的公共卫生负担。本研究旨在报告伊朗CRC的流行病学特征、分子遗传学方面、生存率、遗传情况及筛查模式。方法。进行全面的文献综述以确定相关已发表文章。我们使用了医学主题词，包括结直肠癌、分子遗传学、KRAS和BRAF突变、筛查、生存率、流行病学研究以及伊朗。结果。伊朗CRC的年龄标准化发病率男性为11.6，女性为10.5。总体五年生存率为41%，且CRC在年轻年龄组中的比例高于西方国家。根据种族、地理区域、饮食和遗传易感性，伊朗各地CRC中的突变基因差异很大且各不相同。CRC患者亲属记录中CRC的高发病率表明CRC家族史在年轻CRC患者中更为常见。结论。对于可通过筛查早期发现的CRC，尤其是CRC患者的亲属，应考虑采取适当的筛查策略，这应作为CRC筛查项目的第一步。
