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微血管性心绞痛的当前诊断与治疗策略

Current Diagnostic and Therapeutic Strategies in Microvascular Angina.

作者信息

Mumma Bryn, Flacke Nathalie

机构信息

UC Davis Health System Department of Emergency Medicine 4150 V Street, PSSB #2100 Sacramento, CA 9517 USA.

Service des Urgences 2 Rue Schlumberger Guebwiller, F-68500 France.

出版信息

Curr Emerg Hosp Med Rep. 2015 Mar;3(1):30-37. doi: 10.1007/s40138-014-0059-1.

DOI:10.1007/s40138-014-0059-1
PMID:25685641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4326009/
Abstract

Microvascular angina is common among patients with signs and symptoms of acute coronary syndrome and is associated with an increased risk of cardiovascular and cerebrovascular events. Unfortunately, microvascular is often under-recognized in clinical settings. The diagnosis of microvascular angina relies on assessment of the functional status of the coronary microvasculature. Invasive strategies include acetylcholine provocation, intracoronary Doppler ultrasound, and intracoronary thermodilution; noninvasive strategies include cardiac positron emission tomography (PET), cardiac magnetic resonance, and Doppler echocardiography. Once the diagnosis of microvascular angina is established, treatment is focused on improving symptoms and reducing future risk of cardiovascular and cerebrovascular events. Pharmacologic options and lifestyle modifications for patients with microvascular angina are similar to those for patients with coronary artery disease.

摘要

微血管性心绞痛在有急性冠状动脉综合征体征和症状的患者中很常见,并且与心血管和脑血管事件风险增加相关。不幸的是,微血管性心绞痛在临床环境中常常未得到充分认识。微血管性心绞痛的诊断依赖于对冠状动脉微血管功能状态的评估。有创策略包括乙酰胆碱激发试验、冠状动脉内多普勒超声检查和冠状动脉内热稀释法;无创策略包括心脏正电子发射断层扫描(PET)、心脏磁共振成像和多普勒超声心动图。一旦确诊微血管性心绞痛,治疗重点在于改善症状并降低未来心血管和脑血管事件的风险。微血管性心绞痛患者的药物治疗选择和生活方式改变与冠状动脉疾病患者相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c9/4326009/daa91c39e566/nihms-648753-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c9/4326009/daa91c39e566/nihms-648753-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c9/4326009/daa91c39e566/nihms-648753-f0001.jpg

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本文引用的文献

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Understanding of chest pain in microvascular disease proved by cardiac magnetic resonance image (UMPIRE): study protocol for a randomized controlled trial.通过心脏磁共振成像证实的微血管疾病中胸痛的理解(UMPIRE):一项随机对照试验的研究方案
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Coronary microvascular dysfunction assessed by intracoronary acetylcholine provocation testing is a frequent cause of ischemia and angina in patients with exercise-induced electrocardiographic changes and unobstructed coronary arteries.通过冠状动脉内乙酰胆碱激发试验评估的冠状动脉微血管功能障碍是运动诱发心电图改变且冠状动脉无阻塞的患者缺血和心绞痛的常见原因。
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Clinical usefulness, angiographic characteristics, and safety evaluation of intracoronary acetylcholine provocation testing among 921 consecutive white patients with unobstructed coronary arteries.921 例无阻塞性冠状动脉的白人患者中冠状动脉内乙酰胆碱激发试验的临床实用性、血管造影特征和安全性评估。
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