Department of Medical Imaging, Institut de cardiologie de Montréal, Université de Montréal, Montréal, Québec, Canada.
Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Curr Cardiol Rep. 2020 Jan 28;22(2):9. doi: 10.1007/s11886-020-1261-2.
The aim of this review is to provide an update on the use of positron emission tomography (PET) with myocardial blood flow (MBF) quantification for the diagnosis and management of patients with microvascular disease.
It is now recognized that a large proportion of patients with classical angina and non-obstructive epicardial disease are suffering from microvascular angina. Microvascular angina shares several key features with epicardial coronary disease, including many risk factors. Clinical criteria for the diagnosis of microvascular angina were recently proposed and PET imaging is called to play a central role in evaluation of these patients. Indeed, PET allows non-invasive measurements of MBF and flow reserve, which are altered in microvascular dysfunction. Furthermore, PET with flow quantification provides independent prognostic information and has the potential to monitor response to therapy in microvascular disease. PET with MBF quantification allows detection of microvascular dysfunction and plays a key role in the investigation of patients with suspected microvascular angina.
本文旨在提供心脏血流（MBF）定量正电子发射断层扫描（PET）在微血管疾病患者诊断和治疗中的最新应用。
目前人们已经认识到，很大一部分患有典型心绞痛和非阻塞性心外膜疾病的患者患有微血管性心绞痛。微血管性心绞痛与心外膜冠状动脉疾病有几个关键特征，包括许多危险因素。最近提出了微血管性心绞痛的临床诊断标准，PET 成像被认为在这些患者的评估中发挥核心作用。事实上，PET 可以非侵入性地测量 MBF 和血流储备，而这在微血管功能障碍中是改变的。此外，血流定量 PET 提供独立的预后信息，并且有可能监测微血管疾病治疗的反应。MBF 定量 PET 可检测微血管功能障碍，并在疑似微血管性心绞痛患者的检查中发挥关键作用。
