来那度胺对一名POEMS综合征患者的长期治疗
Long-Term Therapy with Lenalidomide in a Patient with POEMS Syndrome.
作者信息
Chu Benjamin F, Shana'ah Arwa, Hofmeister Craig C, Benson Don M, Sell Megan, Tucker Jill, Pichiorri Flavia, Efebera Yvonne A
机构信息
Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, United States.
Department of Pathology, Ohio State University, Columbus, OH, United States.
出版信息
Eur J Case Rep Intern Med. 2014;1. doi: 10.12890/2014_000093.
Abstract
Lenalidomide is an effective therapy against malignant plasma cells and a potent agent against proinflammatory and proangiogenic cytokines. The use of lenalidomide in POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein with plasma cells, skin changes) has been reported, but its benefit in long-term use is not well established. A 55-year-old man with POEMS and debilitating polyneuropathy was treated with lenalidomide and dexamethasone followed by maintenance lenalidomide. He remains in haematologic remission and in complete recovery of functional status 3.5 years after diagnosis. This case supports the long-term use of lenalidomide in patients with POEMS syndrome.
摘要
来那度胺是一种治疗恶性浆细胞的有效疗法，也是一种对抗促炎和促血管生成细胞因子的强效药物。已有报道来那度胺用于POEMS综合征（多发性神经病变、脏器肿大、内分泌病、伴有浆细胞的单克隆蛋白、皮肤改变）的治疗，但长期使用的益处尚未明确。一名患有POEMS综合征和致残性多发性神经病变的55岁男性接受了来那度胺和地塞米松治疗，随后接受来那度胺维持治疗。诊断3.5年后，他仍处于血液学缓解状态，功能状态完全恢复。该病例支持在POEMS综合征患者中长期使用来那度胺。
相似文献
1
Long-Term Therapy with Lenalidomide in a Patient with POEMS Syndrome.来那度胺对一名POEMS综合征患者的长期治疗
Eur J Case Rep Intern Med. 2014;1. doi: 10.12890/2014_000093.
2
Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites.来那度胺和地塞米松治疗一名伴有大量腹水的POEMS综合征患者
Case Rep Hematol. 2014;2014:818946. doi: 10.1155/2014/818946. Epub 2014 Feb 19.
3
Successful treatment with daratumumab, lenalidomide, and dexamethasone therapy followed by autologous stem cell transplantation for newly diagnosed polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes syndrome: a case report.采用达雷妥尤单抗、来那度胺和地塞米松联合治疗，随后进行自体造血干细胞移植治疗新诊断的多发性神经病、器官肿大、内分泌病、M 蛋白、皮肤改变综合征：一例报告。
J Med Case Rep. 2022 Aug 18;16(1):311. doi: 10.1186/s13256-022-03552-y.
4
Ischemic Stroke in a Patient With Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, and Skin Changes Syndrome Treated With Lenalidomide.来那度胺治疗的伴有多神经病、器官肿大、内分泌病、单克隆蛋白血症和皮肤改变综合征患者的缺血性卒中
Cureus. 2020 Jul 22;12(7):e9346. doi: 10.7759/cureus.9346.
5
Skin Responses in Newly Diagnosed Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome After Therapy With Low-Dose Lenalidomide Plus Dexamethasone.新型 POEMS 综合征（多发性神经病、器官肿大、内分泌病、单克隆丙种球蛋白病及皮肤改变）患者接受低剂量来那度胺联合地塞米松治疗后的皮肤反应。
Front Immunol. 2021 May 6;12:681360. doi: 10.3389/fimmu.2021.681360. eCollection 2021.
6
A prospective phase II study of low dose lenalidomide plus dexamethasone in patients with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome.一项前瞻性 II 期研究，评估低剂量来那度胺联合地塞米松治疗新诊断的多发性神经病、器官肿大、内分泌病、单克隆丙种球蛋白病和皮肤改变（POEMS）综合征患者的疗效。
Am J Hematol. 2018 Jun;93(6):803-809. doi: 10.1002/ajh.25100. Epub 2018 Apr 18.
7
Daratumumab plus lenalidomide and dexamethasone for relapsed POEMS syndrome with bone plasmacytoma harboring 17p deletion.达雷妥尤单抗联合来那度胺和地塞米松治疗伴有17p缺失的骨浆细胞瘤复发的POEMS综合征
Int J Hematol. 2023 Mar;117(3):463-467. doi: 10.1007/s12185-022-03459-w. Epub 2022 Oct 6.
8
Polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes syndrome with dilated cardiomyopathy: A case report.多神经病、器官肿大、内分泌病、M蛋白、皮肤改变综合征伴扩张型心肌病：一例报告。
World J Clin Cases. 2024 Jan 26;12(3):601-606. doi: 10.12998/wjcc.v12.i3.601.
9
Two cases of special POEMS syndrome without monoclonal protein expression: a case report and literature review.两例无单克隆蛋白表达的特殊POEMS综合征病例报告及文献复习
J Int Med Res. 2021 Apr;49(4):300060521990967. doi: 10.1177/0300060521990967.
10
Unusual Types of Plasma Cell Dyscrasias Associated With HIV: Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, and Skin Changes (POEMS) Syndrome.与HIV相关的罕见浆细胞异常增生症：多神经病、器官肿大、内分泌病、M蛋白及皮肤改变（POEMS）综合征
Cureus. 2024 Jun 21;16(6):e62820. doi: 10.7759/cureus.62820. eCollection 2024 Jun.
引用本文的文献
1
Unraveling Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes Syndrome: Diagnostic Challenges and Therapeutic Strategies at a National Tertiary Care Center.解析多神经病、器官肿大、内分泌病、单克隆丙种球蛋白病和皮肤改变综合征：国家三级医疗中心的诊断挑战与治疗策略
Cureus. 2024 Dec 12;16(12):e75620. doi: 10.7759/cureus.75620. eCollection 2024 Dec.
2
Two cases of special POEMS syndrome without monoclonal protein expression: a case report and literature review.两例无单克隆蛋白表达的特殊POEMS综合征病例报告及文献复习
J Int Med Res. 2021 Apr;49(4):300060521990967. doi: 10.1177/0300060521990967.
3
Immune-Mediated Neuropathies.免疫介导的神经病
Curr Treat Options Neurol. 2019 Jun 21;21(6):28. doi: 10.1007/s11940-019-0569-y.
4
Salvage therapy with lenalidomide containing regimen for relapsed/refractory Castleman disease: a report of three cases.硼替佐米联合来那度胺挽救治疗复发/难治性Castleman 病三例报告
Front Med. 2017 Jun;11(2):287-292. doi: 10.1007/s11684-017-0510-2. Epub 2017 Apr 3.
5
Improvement of sexual function in POEMS syndrome after combination therapy of Lenalidomide and dexamethasone.来那度胺与地塞米松联合治疗后POEMS综合征患者性功能的改善
Orphanet J Rare Dis. 2016 Jun 18;11(1):80. doi: 10.1186/s13023-016-0461-8.
6
Kennedy Disease Misdiagnosed as Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome: A Case Report.肯尼迪病误诊为多神经病、器官肿大、内分泌病、单克隆丙种球蛋白病和皮肤改变（POEMS）综合征：一例报告
Med Princ Pract. 2016;25(3):286-9. doi: 10.1159/000442822. Epub 2015 Nov 30.
本文引用的文献
1
New advances in the diagnosis and treatment of POEMS syndrome.POEMS 综合征的诊断与治疗新进展。
Br J Haematol. 2013 May;161(3):303-15. doi: 10.1111/bjh.12236. Epub 2013 Feb 8.
2
POEMS syndrome: update on diagnosis, risk-stratification, and management.POEMS 综合征：诊断、风险分层和治疗的最新进展。
Am J Hematol. 2012 Aug;87(8):804-14. doi: 10.1002/ajh.23288.
3
Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience.POEMS 综合征（硬化性骨髓瘤）患者自体干细胞移植后的长期结果：单中心经验。
Blood. 2012 Jul 5;120(1):56-62. doi: 10.1182/blood-2012-04-423178. Epub 2012 May 18.
4
Lenalidomide after stem-cell transplantation for multiple myeloma.来那度胺用于多发性骨髓瘤患者干细胞移植后。
N Engl J Med. 2012 May 10;366(19):1770-81. doi: 10.1056/NEJMoa1114083.
5
How I treat POEMS syndrome.我如何治疗 POEMS 综合征。
Blood. 2012 Jun 14;119(24):5650-8. doi: 10.1182/blood-2012-03-378992. Epub 2012 Apr 30.
6
POEMS syndrome with severe neurological damage clinically recovered with lenalidomide.伴有严重神经损伤的POEMS综合征经来那度胺治疗后临床康复。
Haematologica. 2012 Feb;97(2):320-2. doi: 10.3324/haematol.2011.041897. Epub 2011 Nov 4.
7
Successful bortezomib-based treatment in POEMS syndrome.基于硼替佐米的治疗方案在POEMS综合征中的成功应用。
Eur J Haematol. 2009 Dec 1;83(6):609-10. doi: 10.1111/j.1600-0609.2009.01330.x. Epub 2009 Aug 6.
8
Lenalidomide therapy in a patient with POEMS syndrome.来那度胺治疗POEMS综合征患者。
Blood. 2007 Aug 1;110(3):1075-6. doi: 10.1182/blood-2007-03-082354.
9
Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature.伴有多发性神经病、器官肿大、内分泌病、M蛋白和皮肤改变的浆细胞异常增生症：POEMS综合征。两例报告并文献复习
Medicine (Baltimore). 1980 Jul;59(4):311-22. doi: 10.1097/00005792-198007000-00006.
Zotero 插件