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糖尿病与非糖尿病波多黎各儿童唾液细胞因子水平的比较:一项病例对照初步研究。

Comparison of Levels of Salivary Cytokines in Diabetic and Nondiabetic Puerto Rican Children: A Case-control Pilot Study.

作者信息

López del Valle Lydia M, Ocasio-López Carlos, Steffen Michelle

机构信息

Surgical Sciences Department, School of Dental Medicine, University of Puerto Rico, Puerto Rico.

Department of Pediatrics, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico; Pediatric Intensive Care Unit, University of Puerto Rico Pediatric Hospital, San Juan, Puerto Rico.

出版信息

Pediatr Dent. 2015 Jan-Feb;37(1):30-4.

Abstract

PURPOSE

The oral health status of children with type 1 diabetes and its relationship to salivary cytokines have been researched in only one known study. The purpose of the present study was to evaluate the association between levels of salivary cytokines and gingival disease in diabetic and nondiabetic Puerto Rican children.

METHODS

A matched case-control study with a convenience sample of 25 children with type 1 diabetes (cases) and 25 nondiabetic children (controls) were evaluated by a calibrated dentist for oral health indices. A five-ml stimulated saliva sample was taken from each subject and analyzed to determine cytokine levels (IL-6, IL-17, IP-10, TNF-alpha, MMP-2, MMP-9, CRP). Descriptive statistics, chi-square tests, and t tests were used.

RESULTS

Diabetic children are observed to have more plaque than control children (P=.007), more calculus (P=.06), and more bleeding on probing (P=.001). Only the level of the mediator IL-17 (P=.002) was higher in diabetic children than in nondiabetic children, but no significant differences were observed in the levels of other cytokines between the two groups. However, for each salivary mediator evaluated, diabetic children had higher levels of the respective mediator.

CONCLUSION

Salivary cytokines levels were higher in diabetic type 1 children than in nondiabetic children.

摘要

目的

仅一项已知研究对1型糖尿病儿童的口腔健康状况及其与唾液细胞因子的关系进行了研究。本研究的目的是评估波多黎各糖尿病和非糖尿病儿童唾液细胞因子水平与牙龈疾病之间的关联。

方法

采用匹配病例对照研究,选取25名1型糖尿病儿童(病例组)和25名非糖尿病儿童(对照组)作为便利样本,由一名经过校准的牙医评估口腔健康指数。从每个受试者采集5毫升刺激唾液样本,分析以确定细胞因子水平(IL-6、IL-17、IP-10、TNF-α、MMP-2、MMP-9、CRP)。使用描述性统计、卡方检验和t检验。

结果

观察到糖尿病儿童比对照儿童有更多的牙菌斑(P = 0.007)、更多的牙结石(P = 0.06)和更多的探诊出血(P = 0.001)。只有介质IL-17的水平在糖尿病儿童中高于非糖尿病儿童(P = 0.002),但两组之间其他细胞因子水平未观察到显著差异。然而,对于评估的每种唾液介质,糖尿病儿童的相应介质水平更高。

结论

1型糖尿病儿童的唾液细胞因子水平高于非糖尿病儿童。

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