Zhang Zhenhuan, Christopher Gordon F
Department of Mechanical Engineering, Texas Tech University, Lubbock, TX 79409, USA.
Soft Matter. 2015 Apr 7;11(13):2596-603. doi: 10.1039/c5sm00131e.
Hyaluronic acid solutions have been widely studied due to their relevance to the rheological behavior of synovial fluid and joint lubrication. Ambulatory joint motion is typically large oscillatory deflections; therefore, large amplitude oscillatory shear strain experiments are used to examine the relevant non-linear viscoelastic properties of these solutions. Using the sequence of physical processes method to analyze data provides time dependent viscoelastic moduli, which exhibit a clear physiologically relevant behavior to hyaluronic acids non-linear viscoelasticity. In particular, it is seen that during peak strain/acceleration, the time dependent elastic modulus peaks and the loss modulus is at a minimum. The hyaluronic acid can provide an immediate elastic response to sudden forces, acting like a shock absorber during sudden changes in direction of motion or maximum deflection. However, during peak rate, the elastic modulus is at a minimum and the loss modulus is at a maximum, which provides greater efficacy to hydrodynamic shear lubrication.
由于透明质酸溶液与滑液的流变行为和关节润滑相关，因此已得到广泛研究。动态关节运动通常是大幅度的振荡偏转；因此，采用大幅度振荡剪切应变实验来研究这些溶液相关的非线性粘弹性特性。使用物理过程序列法分析数据可提供随时间变化的粘弹性模量，其对透明质酸的非线性粘弹性表现出明显的生理相关行为。特别值得注意的是，在应变/加速度峰值期间，随时间变化的弹性模量达到峰值，而损耗模量处于最小值。透明质酸能够对突然施加的力立即产生弹性响应，在运动方向突然改变或最大偏转时起到减震器的作用。然而，在速率峰值期间，弹性模量处于最小值，而损耗模量处于最大值，这为流体动力剪切润滑提供了更高的效能。
