急性主动脉夹层早期诊断的潜在生物标志物。
Potential biomarkers for early diagnosis of acute aortic dissection.
作者信息
Peng Wen, Peng Zhenyu, Chai Xiangping, Zhu Qingyi, Yang Guifang, Zhao Qin, Zhou Shenghua
机构信息
Department of Emergency, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan 410011, China.
Department of Emergency, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan 410011, China.
出版信息
Heart Lung. 2015 May-Jun;44(3):205-8. doi: 10.1016/j.hrtlng.2015.01.006. Epub 2015 Feb 14.
OBJECTIVE
The purpose of this study was to identify biological markers for early diagnosis of acute aortic dissection (AAD).
METHODS
76 patients presented to the emergency room with acute chest pain within 6 h of occurrence were recruited for this study, and AAD diagnosed by aortic CTA. Biomarkers were measured by ELISA. ROC curve and Pearson correlation analysis were used to evaluate the sensitivity and specificity to diagnosis of AAD.
RESULTS
The serum levels of α-SMA, smMHC, sELAF, PC1 and D-dimer were significantly higher in AAD patients than in other groups (P < 0.05). Significant correlations between smMHC, sELAF, PC1, and D-dimer level were observed in AAD. Any combination of two markers showed good sensitivity (94.29%) and specificity (85.37%).
CONCLUSION
smMHC, sELAF, PC1, or D-dimer alone is a biomarker for early diagnosis of AAD, but the combination of these markers has significantly higher diagnostic value.
目的
本研究旨在确定急性主动脉夹层（AAD）早期诊断的生物标志物。
方法
本研究招募了76例在发病6小时内因急性胸痛就诊于急诊室的患者，通过主动脉CTA诊断为AAD。采用酶联免疫吸附测定法（ELISA）检测生物标志物。采用ROC曲线和Pearson相关分析评估对AAD诊断的敏感性和特异性。
结果
AAD患者血清α-SMA、smMHC、sELAF、PC1和D-二聚体水平显著高于其他组（P<0.05）。在AAD患者中观察到smMHC、sELAF、PC1和D-二聚体水平之间存在显著相关性。两种标志物的任何组合均显示出良好的敏感性（94.29%）和特异性（85.37%）。
结论
单独的smMHC、sELAF、PC1或D-二聚体是AAD早期诊断的生物标志物，但这些标志物的组合具有显著更高的诊断价值。
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