三维细菌纤维素基纳米纤维表面控制的磷酸钙形成。
Surface controlled calcium phosphate formation on three-dimensional bacterial cellulose-based nanofibers.
机构信息
School of Materials Science and Engineering, Tianjin University, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin 300072, PR China.
School of Mechanical and Electrical Engineering, East China Jiaotong University, Nanchang, Jiangxi 330013, PR China.
出版信息
Mater Sci Eng C Mater Biol Appl. 2015 Apr;49:526-533. doi: 10.1016/j.msec.2015.01.053. Epub 2015 Jan 15.
Studies on the early calcium phosphate (Ca-P) formation on nanosized substrates may allow us to understand the biomineralization mechanisms at the molecular level. In this work, in situ formation of Ca-P minerals on bacterial cellulose (BC)-based nanofibers was investigated, for the first time, using the X-ray absorption near-edge structure (XANES) spectroscopy. In addition, the influence of the surface coating of nanofibers on the formation of Ca-P minerals was determined. Combined with XRD analysis, XANES results revealed that the nascent precursor was ACP (amorphous calcium phosphate) which was converted to TCP (β-tricalcium phosphate), then OCP (octacalcium phosphate), and finally to HAP (hydroxyapatite) when phosphorylated BC nanofibers were the templates. However, the formation of nascent precursor and its transformation process varied depending on the nature of the coating material on nanofibrous templates. These results provide new insights into basic mechanisms of mineralization and can lead to the development of novel bioinspired nanostructured materials.
研究纳米级基底上早期磷酸钙（Ca-P）的形成情况，可能使我们能够在分子水平上理解生物矿化机制。在这项工作中，首次使用 X 射线吸收近边结构（XANES）光谱法研究了细菌纤维素（BC）基纳米纤维上 Ca-P 矿物的原位形成情况。此外，还确定了纳米纤维表面涂层对 Ca-P 矿物形成的影响。结合 XRD 分析，XANES 结果表明，初生前体是 ACP（无定形磷酸钙），当磷酸化 BC 纳米纤维作为模板时，它会转化为 TCP（β-磷酸三钙），然后是 OCP（八钙磷酸盐），最后是 HAP（羟基磷灰石）。然而，初生前体的形成及其转化过程取决于纳米纤维模板上涂层材料的性质。这些结果为矿化的基本机制提供了新的见解，并可能导致新型仿生纳米结构材料的开发。
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