Department of Ceramic Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Department of Ceramic Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Mater Sci Eng C Mater Biol Appl. 2015 Apr;49:549-559. doi: 10.1016/j.msec.2015.01.049. Epub 2015 Jan 12.
Barium with low concentration in the glasses acts as a muscle stimulant and is found in human teeth. We have made a primary study by substituting barium in the bioactive glass. The chemical composition containing (46.1-X) SiO2--24.3 Na2O-26.9 CaO-2.6 P2O5, where X=0, 0.4, 0.8, 1.2 and 1.6mol% of BaO was chosen and melted in an electric furnace at 1400±5°C. The glasses were characterized to determine their use in biomedical applications. The nucleation and crystallization regimes were determined by DTA and the controlled crystallization was carried out by suitable heat treatment. The crystalline phase formed was identified by using XRD technique. Bioactivity of these glasses was assessed by immersion in simulated body fluid (SBF) for various time periods. The formation of hydroxy carbonate apatite (HCA) layer was identified by FTIR spectrometry, scanning electron microscope (SEM) and XRD which showed the presence of HCA as the main phase in all tested bioactive glass samples. Flexural strength and densities of bioactive glasses have been measured and found to increase with increasing the barium content. The human blood compatibility of the samples was evaluated and found to be pertinent.
玻璃中低浓度的钡具有肌肉刺激作用，存在于人类牙齿中。我们通过在生物活性玻璃中替代钡进行了初步研究。选择了化学组成含（46.1-X）SiO2--24.3 Na2O-26.9 CaO-2.6 P2O5，其中 X=0、0.4、0.8、1.2 和 1.6mol%的 BaO，并在 1400±5°C 的电炉中熔化。通过差热分析（DTA）确定了成核和结晶制度，并通过适当的热处理进行了受控结晶。通过 XRD 技术确定了形成的晶体相。通过将这些玻璃在模拟体液（SBF）中浸泡不同时间来评估其生物活性。通过傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）和 XRD 鉴定了羟基碳酸磷灰石（HCA）层的形成，表明所有测试的生物活性玻璃样品中均以 HCA 作为主要相存在。测量了生物活性玻璃的抗弯强度和密度，发现随着钡含量的增加而增加。评估了样品的人体血液相容性，发现其相关。
