Kovrlija Ilijana, Locs Janis, Loca Dagnija
Rudolfs Cimdins Riga Biomaterials Innovation and Development Centre, Faculty of Materials Science and Applied Chemistry, Institute of General Chemical Engineering, Riga Technical University, Pulka 3, LV-1007 Riga, Latvia.
Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Kaļķu Street 1, LV-1658 Riga, Latvia.
Materials (Basel). 2021 Oct 2;14(19):5772. doi: 10.3390/ma14195772.
In the present manuscript, a brief overview on barium, its possible utilization, and the aftermath of its behavior in organisms has been presented. As a bivalent cation, barium has the potential to be used in a myriad of biochemical reactions. A number of studies have exhibited both the unwanted outcome barium displayed and the advantages of barium laden compounds, tested in in vitro and in vivo settings. The plethora of prospective manipulations covered the area of hydrogels and calcium phosphates, with an end goal of examining barium's future in the tissue engineering. However, majority of data revert to the research conducted in the 20th century, without investigating the mechanisms of action using current state-of-the-art technology. Having this in mind, set of questions that are needed for possible future research arose. Can barium be used as a substitute for other biologically relevant divalent cations? Will the incorporation of barium ions hamper the execution of the essential processes in the organism? Most importantly, can the benefits outweigh the harm?
在本手稿中，对钡、其可能的用途以及它在生物体中的行为后果进行了简要概述。作为一种二价阳离子，钡有潜力用于无数的生化反应。一些研究展示了钡所表现出的不良后果以及含钡化合物的优势，这些研究是在体外和体内环境中进行测试的。大量的前瞻性操作涵盖了水凝胶和磷酸钙领域，最终目标是研究钡在组织工程中的未来应用。然而，大多数数据可追溯到20世纪进行的研究，而没有使用当前的先进技术来研究其作用机制。考虑到这一点，就出现了未来可能研究所需的一系列问题。钡能否用作其他具有生物学相关性的二价阳离子的替代品？钡离子的掺入是否会妨碍生物体中基本过程的执行？最重要的是，益处能否超过危害？
