Kaji R, Happel L, Sumner A J
Department of Neurology, Kyoto University Hospital, Japan.
Ann Neurol. 1990 Oct;28(4):582-4. doi: 10.1002/ana.410280419.
Digitalis has been shown to reverse conduction block in demyelinated nerve fibers in experimental animals. In the search for a symptomatic treatment of multiple sclerosis, digoxin (0.02 mg per kilogram of body weight) was given intravenously to 7 patients with probable or clinically definite multiple sclerosis. All of these patients had temperature-dependent symptoms. In 3 patients, improvement of clinical deficits was observed concurrent with significant changes in evoked potential findings. Digitalis derivatives may be useful in ameliorating symptoms in selected patients with multiple sclerosis.
洋地黄已被证明可逆转实验动物脱髓鞘神经纤维中的传导阻滞。为寻找多发性硬化症的对症治疗方法，对7例可能患有或临床确诊为多发性硬化症的患者静脉注射地高辛（每公斤体重0.02毫克）。所有这些患者都有温度依赖性症状。3例患者在诱发电位结果发生显著变化的同时，临床缺陷得到改善。洋地黄衍生物可能有助于改善部分多发性硬化症患者的症状。
