β-肾上腺素能受体阻断药物与离体大鼠肥大细胞中的钙转运
Beta-adrenoceptor blocking drugs and calcium transport in isolated rat mast cells.
作者信息
Drábiková K, Pecivová J, Nosál R
机构信息
Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
出版信息
Agents Actions. 1989 Apr;27(1-2):33-5. doi: 10.1007/BF02222190.
The beta-adrenoceptor blocking (BAB) drugs exaprolol (EXA), metipranolol (MET) and propranolol (PRO) inhibited histamine liberation and degranulation from isolated rat mast cells stimulated with the calcium ionophore A23187. MET was the most and EXA the least active. Atenolol (ATE) had no effect. Inhibition by BAB drugs of secretion induced with A23187 was not accompanied by any change in 45Ca uptake. On the other hand, EXA, MET and PRO significantly decreased 45Ca uptake by mast cells stimulated with 48/80. The effect of BAB drugs on inhibition of A23187-induced secretion from isolated mast cells was dependent on the lipid solubility of the studied drugs.
β-肾上腺素能受体阻断（BAB）药物依沙洛尔（EXA）、美替洛尔（MET）和普萘洛尔（PRO）可抑制由钙离子载体A23187刺激的离体大鼠肥大细胞释放组胺和脱颗粒。MET活性最强，EXA活性最弱。阿替洛尔（ATE）无作用。BAB药物对A23187诱导的分泌的抑制作用不伴有45Ca摄取的任何变化。另一方面，EXA、MET和PRO可显著降低由48/80刺激的肥大细胞对45Ca的摄取。BAB药物对抑制离体肥大细胞A23187诱导的分泌的作用取决于所研究药物的脂溶性。
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