动物静脉注射和枕下注射碘曲仑后的组织分布与排泄

Tissue distribution and excretion of iotrolan after intravenous and suboccipital injections in animals.

作者信息

Weinmann H J, Scholz P, Mützel W

出版信息

Fortschr Geb Rontgenstrahlen Nuklearmed Erganzungsbd. 1989;128:206-10.

Abstract

The fate of iotrolan in the body is determined by its physicochemical characteristics and biologic inertness. Iotrolan is distributed in the extracellular space after intravenous or intracisternal injections. No absorption occurred after oral administration. Iotrolan is eliminated almost exclusively by renal excretion in an unmetabolized form. The results found are very similar to those published for other x-ray contrast agents used in uroangiography.

摘要

碘曲仑在体内的命运由其物理化学特性和生物惰性决定。静脉注射或脑池内注射后，碘曲仑分布于细胞外间隙。口服给药后不发生吸收。碘曲仑几乎完全以未代谢的形式经肾排泄消除。所发现的结果与用于尿路血管造影的其他X射线造影剂所发表的结果非常相似。