Tissue distribution and excretion of iotrolan after intravenous and suboccipital injections in animals.

The fate of iotrolan in the body is determined by its physicochemical characteristics and biologic inertness. Iotrolan is distributed in the extracellular space after intravenous or intracisternal injections. No absorption occurred after oral administration. Iotrolan is eliminated almost exclusively by renal excretion in an unmetabolized form. The results found are very similar to those published for other x-ray contrast agents used in uroangiography.