Weinmann H J, Vogelsang H, Mützel W, Speck U
Fortschr Geb Rontgenstrahlen Nuklearmed Erganzungsbd. 1989;128:224-7.
Ten milliliters of iotrolan containing 240 mg I/ml were injected into the lower lumbar subarachnoid space of ten patients. Plasma level and urinary and fecal excretion were monitored for 3 days after injection. The mean iodine concentration in the plasma of about 50 micrograms/ml (6% of the dose given in the total plasma volume) peaked at 1 to 2 hours after injection. After reaching the maximum values, the iotrolan concentration in the plasma decreased with a half-life of about 4 hours (median value). About 90% of the injected dose was found in the urine and about 1% was detected in the feces.
将含有240毫克碘/毫升的碘曲仑10毫升注入10名患者的下腰椎蛛网膜下腔。注射后3天监测血浆水平以及尿液和粪便排泄情况。血浆中碘的平均浓度约为50微克/毫升（占注入全血容量剂量的6%），在注射后1至2小时达到峰值。达到最大值后，血浆中碘曲仑的浓度下降，半衰期约为4小时（中位数）。约90%的注入剂量在尿液中被发现，约1%在粪便中被检测到。
