健康志愿者静脉注射碘曲仑后的药代动力学

Pharmacokinetics of iotrolan after intravenous injection into healthy volunteers.

作者信息

Scholz P, Weinmann H J, Mützel W, Staks T

出版信息

Fortschr Geb Rontgenstrahlen Nuklearmed Erganzungsbd. 1989;128:211-4.

Abstract

In man Iotrolan is distributed in the extravascular space after intravenous injection with a half-life of about 11 minutes, the elimination half-life being about 108 minutes. After intravenous injection 99.2 +/- 1.8% of the dose was found in the urine and 0.5 +/- 0.1% in the feces within 5 days. No metabolization occurred in man and the pharmacokinetic behavior of iotrolan is comparable to that of known nonionic contrast media (e.g., iohexol, iopromide) (7, 9, 13).

摘要

在人体中，静脉注射后碘曲仑分布于血管外间隙，半衰期约为11分钟，消除半衰期约为108分钟。静脉注射后，5天内99.2±1.8%的剂量经尿液排出，0.5±0.1%经粪便排出。人体中未发生代谢，碘曲仑的药代动力学行为与已知的非离子型造影剂（如碘海醇、碘普罗胺）相当(7, 9, 13)。