羟基酪醇和酪醇酯在二油酰磷脂酰胆碱（DOPC）脂质体双层中的分配、位置及其对脂质体双层行为的影响。

Hydroxytyrosol and tyrosol esters partitioning into, location within, and effect on DOPC liposome bilayer behavior.

作者信息

Evans Kervin O, Laszlo Joseph A, Compton David L

机构信息

Renewable Products Technology Research Unit, National Center of Agricultural Utilization Research Center, Agricultural Research Service, U.S. Department of Agriculture, 1815 N. University Street, Peoria, IL 61604, USA.

出版信息

Biochim Biophys Acta. 2015 May;1848(5):1175-82. doi: 10.1016/j.bbamem.2015.02.002. Epub 2015 Feb 14.

DOI:10.1016/j.bbamem.2015.02.002

PMID:25687972

Abstract

The phenols hydroxytyrosol and tyrosol made abundantly available through olive oil processing were enzymatically transesterified into effective lipophilic antioxidants with cuphea oil. The hydroxytyrosyl and tyrosyl esters made from cuphea oil were assessed for their ability to partition into, locate within and effect the bilayer behavior of 1,2-dioloeoylphosphatidylcholine liposomes and compared to their counterparts made from decanoic acid. Partitioning into liposomes was on the same scale for both hydroxytyrosyl derivatives and both tyrosyl derivatives. All were found to locate nearly at the same depth within the bilayer. Each was found to affect bilayer behavior in a distinct manner.

摘要

通过橄榄油加工大量可得的酚类物质羟基酪醇和酪醇与卡诺拉油进行酶促酯交换反应，生成有效的亲脂性抗氧化剂。对由卡诺拉油制成的羟基酪醇酯和酪醇酯进行了评估，以确定它们分配到1,2 - 二油酰磷脂酰胆碱脂质体中、在脂质体内定位以及影响脂质体双层行为的能力，并与由癸酸制成的对应物进行了比较。羟基酪醇衍生物和酪醇衍生物在分配到脂质体方面处于相同水平。发现所有这些酯在双层内的定位深度几乎相同。还发现每种酯以独特的方式影响双层行为。