Chen Zhen, Li Meng-Tao, Xu Dong, Leng Xiao-Mei, Wang Qian, Tian Xin-Ping, Zhang Shang-Zhu, Zhao Yan, Zeng Xiao-Feng
Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, People's Republic China.
Clin Rheumatol. 2015 Aug;34(8):1383-9. doi: 10.1007/s10067-015-2884-3. Epub 2015 Feb 18.
With this study, we provide insight into the clinical characteristics, laboratory characteristics, and organ damage associated with incomplete lupus syndromes (ILE) and search for predictors of organ damage in ILE. A retrospective chart review was performed on 77 hospitalized patients with ILE. The control patient group comprised 2104 systemic lupus erythematosus (SLE) patients who were entered into the Chinese SLE Treatment and Research group (CSTAR). The Systemic Lupus International Collaborating Clinics (SLICC)/ACR Damage Index (SDI) was used to classify damage features. Based on their SDI score, ILE patients were divided into SDI > 0 and SDI = 0 groups. The percentages of anti-SSA-seropositive (54.5 %) and anti-RNP-seropositive (24.7 %) patients with ILE were higher than those found among the SLE patients from CSTAR (p < 0.001). The mean SDI score was 0.66 (range 0-2), and a damage score greater than 0 was present in 41 (53.3 %) patients. The most prevalent damage category was pulmonary damage, present in 17 (22.1 %) patients. Peripheral vascular damage occurred in individuals who were significantly older than those who had musculoskeletal damage (p = 0.031). The subgroup with SDI > 0 had a higher mean age (36.8 ± 2.04 years) than those with SDI = 0 (30.8 ± 2.08 years; p = 0.044). The mean SLEDAI score in the SDI > 0 patient group (8.2 ± 0.74) was higher than that of the SDI = 0 group (4.8 ± 0.54; p = 0.001). ILE patients may include a subset that is likely to experience progressive organ damage. Organ damage was more common in patients of older age and with high SLEDAI scores.
通过本研究，我们深入了解了不完全性狼疮综合征（ILE）的临床特征、实验室特征及相关器官损害情况，并探寻ILE患者器官损害的预测因素。对77例住院的ILE患者进行了回顾性病历审查。对照组患者为2104例纳入中国系统性红斑狼疮治疗与研究组（CSTAR）的系统性红斑狼疮（SLE）患者。采用系统性红斑狼疮国际协作临床诊所（SLICC）/美国风湿病学会（ACR）损伤指数（SDI）对损伤特征进行分类。根据SDI评分，ILE患者被分为SDI＞0组和SDI = 0组。ILE患者中抗SSA抗体阳性（54.5%）和抗RNP抗体阳性（24.7%）的比例高于CSTAR的SLE患者（p＜0.001）。SDI平均评分为0.66（范围0 - 2），41例（53.3%）患者的损伤评分大于0。最常见的损伤类型是肺部损伤，17例（22.1%）患者出现该损伤。外周血管损伤患者的年龄显著大于肌肉骨骼损伤患者（p = 0.031）。SDI＞0亚组的平均年龄（36.8±2.04岁）高于SDI = 0亚组（30.8±2.08岁；p = 0.044）。SDI＞0患者组的SLEDAI平均评分（8.2±0.74）高于SDI = 0组（4.8±0.54；p = 0.001）。ILE患者可能包括一部分有发生进行性器官损害倾向的亚组。器官损害在年龄较大且SLEDAI评分较高的患者中更为常见。
