Živković Valentina, Mitić Branka, Stamenković Bojana, Stojanović Sonja, Dinić Biljana Radovanović, Stojanović Miodrag, Jurišić Vladimir
MD, PhD. Assistant Professor, Faculty of Medicine, University of Niš, and Institute for Treatment and Rehabilitation "Niška Banja", Niš, Serbia.
MD, PhD. Assistant Professor, Faculty of Medicine, University of Niš, and Clinic of Nephrology, Clinical Centre, Niš, Serbia.
Sao Paulo Med J. 2019 Jul 15;137(2):155-161. doi: 10.1590/1516-3180.2018.0258060219.
Organ damage in patients with systemic lupus erythematosus (SLE) occurs as a consequence of the disease itself, the therapy applied and the accompanying conditions and complications. Organ damage predicts further organ damage and is associated with an increased risk of death.
This study aimed to assess the degree of irreversible organ changes in SLE patients, using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI); to establish correlations between organ damage and disease activity, quality of life, intensity of fatigue and serological factors; and to ascertain the risk factors for organ damage.
Cross-sectional single-center study conducted at the Institute for Treatment and Rehabilitation "Niška Banja", Niš, Serbia.
83 patients with SLE were enrolled: 58 patients formed the group with organ damage (SDI ≥ 1), and 25 patients without organ damage served as controls (SDI = 0).
Organ damage correlated with age (P = 0.002), disease duration (P = 0.015), disease activity (grade 1, P = 0.014; and grade 2, P = 0.007), poor quality of life, severe fatigue (P = 0.047) and treatment with azathioprine (P = 0.037). The following factors were protective: use of hydroxychloroquine (P = 0.048) and higher scores obtained for the physical (P = 0.011), mental (P = 0.022) and general health (P = 0.008) domains.
It is very important to evaluate risk factors for organ damage in the body, including physicians' overall assessment, to try to positively influence better treatment outcomes.
系统性红斑狼疮（SLE）患者的器官损害是由疾病本身、所应用的治疗方法以及伴随的状况和并发症导致的。器官损害预示着进一步的器官损害，并与死亡风险增加相关。
本研究旨在使用系统性红斑狼疮国际协作临床中心/美国风湿病学会（SLICC/ACR）损伤指数（SDI）评估SLE患者不可逆器官改变的程度；建立器官损害与疾病活动度、生活质量、疲劳强度和血清学因素之间的相关性；并确定器官损害的危险因素。
在塞尔维亚尼什的“尼什卡巴尼亚”治疗与康复研究所进行的横断面单中心研究。
纳入83例SLE患者：58例患者组成有器官损害组（SDI≥1），25例无器官损害患者作为对照组（SDI = 0）。
器官损害与年龄（P = 0.002）、疾病持续时间（P = 0.015）、疾病活动度（1级，P = 0.014；2级，P = 0.007）、生活质量差、严重疲劳（P = 0.047）以及硫唑嘌呤治疗（P = 0.037）相关。以下因素具有保护作用：使用羟氯喹（P = 0.048）以及身体（P = 0.011）、心理（P = 0.022）和总体健康（P = 0.008）领域获得的较高评分。
评估身体器官损害的危险因素非常重要，包括医生的全面评估，以试图积极影响更好的治疗结果。
