Departament de Química Inorgànica, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona (Spain).
Angew Chem Int Ed Engl. 2015 Apr 7;54(15):4561-5. doi: 10.1002/anie.201412157. Epub 2015 Feb 16.
The photoactivation of potential anticancer metal complexes is a hot topic of current research as it may lead to the development of more selective drugs. Photoactivated chemotherapy (PACT) with coordination compounds is usually based on a (photo)chemical reaction taking place at the metal center. Herein, a new strategy is exploited that consists of "photomodifying" a ligand coordinated to metal ions. Platinum(II) complexes from photoswitchable 1,2-dithienylethene-containing ligands have been prepared, which exhibit two interconvertible photoisomeric forms that present distinct DNA-interacting properties and cytotoxic behaviors.
光激活潜在的抗癌金属配合物是当前研究的热门话题，因为它可能会导致更具选择性的药物的开发。基于金属中心发生的（光）化学反应的配位化合物光激活化疗（PACT）通常是。本文开发了一种新策略，即“光修饰”配位在金属离子上的配体。制备了含有可光致变色 1,2-二噻烯的配体的光致变色铂 (II) 配合物，其具有两种可互变的光异构体形式，表现出不同的 DNA 相互作用特性和细胞毒性行为。
