Li Yanchuan, Wang Cheng, Huai Qingjie, Guo Fuchuan, Liu Liyan, Feng Rennan, Sun Changhao
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
National Key Discipline, School of Public Health, Harbin Medical University, Harbin, China.
Diabetes Metab Res Rev. 2016 Jan;32(1):2-10. doi: 10.1002/dmrr.2641. Epub 2015 Apr 21.
As consumption of tea has been confirmed as a protective factor for type 2 diabetes mellitus (T2DM), it would be interesting to know if T2DM patients could benefit from tea. Because of small sample sizes and inconsistent results of previous studies, we performed this meta-analysis to reevaluate the effects of tea or tea extract on all available outcomes in patients with T2DM. We systematically searched electronic databases of PubMed, Cochrane Library and EMBASE to identify randomized controlled trials of tea in T2DM patients up to January 2015. Weight mean differences for the changes in all outcomes were pooled by Review Manager 5.2 (Cochrane Collaboration, Oxford, England). A total of ten trials including 608 subjects were identified. The meta-analysis found that tea could alleviate the decrease of fasting blood insulin [1.30 U/L, 95% CI (0.36, 2.24)], and reduced waist circumference only in more than 8-week intervention [-2.70 cm, 95% CI (-4.72, -0.69)], whereas there were no statistically significant differences with regard to homeostasis model of insulin resistance 0.38 (-0.18, 0.95), fasting blood glucose -0.05 mmol/L (-0.51, 0.40), low density lipoprotein-cholesterol 0.07 mmol/L (-0.15, 0.29), high density lipoprotein-cholesterol 0.01 mmol/L (-0.08, 0.09), body mass index -0.15 kg/m(2) (-0.50, 0.21), SBP 0.35 mmHg (-3.54, 4.24), DBP -1.02 mmHg (-3.53, 1.48), triglycerides -0.11 mmol/L (-0.28, 0.05) and fasting cholesterol -0.05 mmol/L (-0.20, 0.11) in patients with T2DM, and leptin, ADPN, CRE and UA were also non-significant. The intervention of tea or tea extraction could maintain a stable fasting blood insulin and reduce waist circumference in the T2DM patients; however, the effects on other outcomes were not significant. Copyright © 2015 John Wiley & Sons, Ltd.
由于饮茶已被确认为2型糖尿病（T2DM）的一个保护因素，因此了解T2DM患者是否能从茶中获益将会很有意思。鉴于既往研究样本量小且结果不一致，我们进行了这项荟萃分析，以重新评估茶或茶提取物对T2DM患者所有可用结局指标的影响。我们系统检索了PubMed、Cochrane图书馆和EMBASE的电子数据库，以识别截至2015年1月有关T2DM患者饮茶的随机对照试验。所有结局指标变化的加权平均差采用Review Manager 5.2（Cochrane协作网，英国牛津）进行汇总。共纳入10项试验，包括608名受试者。荟萃分析发现，茶可以缓解空腹血胰岛素的降低[1.30 U/L，95%CI（0.36，2.24）]，且仅在干预8周以上时能减小腰围[-2.70 cm，95%CI（-4.72，-0.69）]，而在胰岛素抵抗稳态模型0.38（-0.18，0.95）、空腹血糖-0.05 mmol/L（-0.51，0.40）、低密度脂蛋白胆固醇0.07 mmol/L（-0.15，0.29）、高密度脂蛋白胆固醇0.01 mmol/L（-0.08，0.09）、体重指数-0.15 kg/m²（-0.50，0.21）、收缩压0.35 mmHg（-3.54，4.24）、舒张压-1.02 mmHg（-3.53，1.48）、甘油三酯-0.11 mmol/L（-0.28，0.05）和空腹胆固醇-0.05 mmol/L（-0.20，0.11）方面，T2DM患者与对照组之间无统计学显著差异，且瘦素、脂联素、肌酐和尿酸的差异也无统计学意义。茶或茶提取物干预可使T2DM患者空腹血胰岛素保持稳定并减小腰围；然而，对其他结局指标的影响不显著。版权所有© 2015约翰威立父子有限公司。
