Zhang Jieying, Wu Kunlu, Xiao Xiaojuan, Liao Jiling, Hu Qikang, Chen Huiyong, Liu Jing, An Xiuli
State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, China.
Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA.
Int J Mol Sci. 2015 Feb 13;16(2):4083-94. doi: 10.3390/ijms16024083.
Autophagy is a process that leads to the degradation of unnecessary or dysfunctional cellular components and long-lived protein aggregates. Erythropoiesis is a branch of hematopoietic differentiation by which mature red blood cells (RBCs) are generated from multi-potential hematopoietic stem cells (HSCs). Autophagy plays a critical role in the elimination of mitochondria, ribosomes and other organelles during erythroid terminal differentiation. Here, the modulators of autophagy that regulate erythroid differentiation were summarized, including autophagy-related (Atg) genes, the B-cell lymphoma 2 (Bcl-2) family member Bcl-2/adenovirus E1B 19 kDa interacting protein 3-like (Nix/Binp3L), transcription factors globin transcription factor 1 (GATA1) and forkhead box O3 (FoxO3), intermediary factor KRAB-associated protein1 (KAP1), and other modulators, such as focal adhesion kinase family-interacting protein of 200-kDa (FIP200), Ca2+ and 15-lipoxygenase. Understanding the modulators of autophagy in erythropoiesis will benefit the autophagy research field and facilitate the prevention and treatment of autophagy-related red blood cell disorders.
自噬是一个导致不必要或功能失调的细胞成分以及长寿蛋白聚集体降解的过程。红细胞生成是造血分化的一个分支，通过该过程，成熟红细胞（RBC）由多能造血干细胞（HSC）产生。自噬在红系终末分化过程中对线粒体、核糖体和其他细胞器的清除起着关键作用。在此，总结了调节红细胞生成的自噬调节因子，包括自噬相关（Atg）基因、B细胞淋巴瘤2（Bcl-2）家族成员Bcl-2/腺病毒E1B 19 kDa相互作用蛋白3样（Nix/Binp3L）、转录因子珠蛋白转录因子1（GATA1）和叉头框O3（FoxO3）、中间因子KRAB相关蛋白1（KAP1），以及其他调节因子，如粘着斑激酶家族相互作用蛋白200 kDa（FIP200）、Ca2+和15-脂氧合酶。了解红细胞生成中自噬的调节因子将有益于自噬研究领域，并促进自噬相关红细胞疾病的预防和治疗。
Zotero 插件