Chang Hsin-Hou, Liou Yu-Shan, Sun Der-Shan
Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan.
Tzu Chi Med J. 2024 Sep 5;36(4):349-359. doi: 10.4103/tcmj.tcmj_100_24. eCollection 2024 Oct-Dec.
Inflammation and stem cell mobilization or homing play pivotal roles in tissue repair and regeneration. This review explores their intricate interplay, elucidating their collaborative role in maintaining tissue homeostasis and responding to injury or disease. While examining the fundamentals of stem cells, we detail the mechanisms underlying inflammation, including immune cell recruitment and inflammatory mediator release, highlighting their self-renewal and differentiation capabilities. Central to our exploration is the modulation of hematopoietic stem cell behavior by inflammatory cues, driving their mobilization from the bone marrow niche into circulation. Key cytokines, chemokines, growth factors, and autophagy, an intracellular catabolic mechanism involved in this process, are discussed alongside their clinical relevance. Furthermore, mesenchymal stem cell homing in response to inflammation contributes to tissue repair processes. In addition, we discuss stem cell resilience in the face of inflammatory challenges. Moreover, we examine the reciprocal influence of stem cells on the inflammatory milieu, shaping immune responses and tissue repair. We underscore the potential of targeting inflammation-induced stem cell mobilization for regenerative therapies through extensive literature analysis and clinical insights. By unraveling the complex interplay between inflammation and stem cells, this review advances our understanding of tissue repair mechanisms and offers promising avenues for clinical translation in regenerative medicine.
炎症与干细胞动员或归巢在组织修复和再生中起着关键作用。本综述探讨了它们之间复杂的相互作用，阐明了它们在维持组织稳态以及对损伤或疾病作出反应方面的协同作用。在研究干细胞基本原理的同时，我们详细阐述了炎症的潜在机制，包括免疫细胞募集和炎症介质释放，突出了干细胞的自我更新和分化能力。我们探索的核心是炎症信号对造血干细胞行为的调节，促使它们从骨髓微环境动员到循环中。文中讨论了关键的细胞因子、趋化因子、生长因子以及自噬（此过程中涉及的一种细胞内分解代谢机制）及其临床相关性。此外，间充质干细胞对炎症的归巢有助于组织修复过程。另外，我们还讨论了干细胞面对炎症挑战时的恢复能力。而且，我们研究了干细胞对炎症环境的相互影响，这种影响塑造了免疫反应和组织修复。通过广泛的文献分析和临床见解，我们强调了针对炎症诱导的干细胞动员进行再生治疗的潜力。通过揭示炎症与干细胞之间的复杂相互作用，本综述增进了我们对组织修复机制的理解，并为再生医学的临床转化提供了有前景的途径。
